نتایج جستجو برای: inos protein

تعداد نتایج: 1236459  

Journal: :Experimental cell research 2003
Andrea Witteck Ying Yao Marcel Fechir Ulrich Förstermann Hartmut Kleinert

Rho proteins (Rho, Rac, Cdc 42) are known to control the organization of the actin cytoskeleton as well as gene expression. Inhibition of Rho proteins by Clostridium difficile toxin B disrupted the F-actin cytoskeleton and enhanced cytokine-induced inducible nitric oxide synthase (iNOS) expression in human epithelial cells. Also specific inhibition by Y-27632 of p160ROCK, which mediates Rho eff...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009
Lavannya Pandit Katarzyna E Kolodziejska Shenyan Zeng N Tony Eissa

Nitric Oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been implicated in the pathogenesis of various biological and inflammatory disorders. Recent evidence suggests that aggresome formation is a physiologic stress response not limited to misfolded proteins. That stress response, termed "physiologic aggresome," is exemplified by aggresome formation of iNOS, an important host...

Neuropathic pain is a complication of inflammation, infection or some diseases such as diabetes. Opioids are used as a salvage therapy for neuropathic pain but tolerance restricts their use. In our previous study we have observed an increase of Nitric Oxide in diabetes and in morphine tolerance. This study was performed to clarify the role of inducible nitric oxide synthase, iNOS, and cationic ...

Journal: :Journal of applied physiology 2007
Juliann G Kiang Phillip D Bowman Xinyue Lu Yansong Li Brian W Wu Horace H Loh K T Tsen George C Tsokos

Hemorrhage has been shown to increase inducible nitric oxide synthase (iNOS) and deplete ATP levels in tissues and geldanamycin limits both processes. Moreover, it is evident that inhibition of iNOS reduces caspase-3 and increases survival. Thus we sought to identify the molecular events responsible for the beneficial effect of geldanamycin. Hemorrhage in mice significantly increased caspase-3 ...

Journal: :Journal of immunology 2002
Alain P Gobert Benjamin D Mersey Yulan Cheng Darren R Blumberg Jamie C Newton Keith T Wilson

Inducible NO synthase (iNOS) expression and production of NO are both up-regulated with Helicobacter pylori infection in vivo and in vitro. We determined whether major pathogenicity proteins released by H. pylori activate iNOS by coculturing macrophages with wild-type or mutant strains deficient in VacA, CagA, picB product, or urease (ureA(-)). When filters were used to separate H. pylori from ...

Journal: :American journal of physiology. Renal physiology 2001
M Porst A Hartner H Krause K F Hilgers R Veelken

This study was designed to test the hypothesis that glomerular de novo expression of inducible nitric oxide synthase (iNOS) contributes to renal hemodynamic abnormalities in liver cirrhosis developed 3 wk after common bile duct ligature (CBDL). De novo expression of iNOS mRNA was detected by RT-PCR in RNA extracts from isolated CBDL rat glomeruli whereas no iNOS mRNA was found in control rat gl...

2015
Latika Nagpal Koustubh Panda

Nitric-Oxide Synthase (NOS), that produces the biological signal molecule Nitric-Oxide (NO), exists in three different isoforms called, neuronal (nNOS), endothelial (eNOS) and inducible (iNOS). All NOS isoforms require post-translational interaction with the calcium-binding protein, calmodulin (CaM) for manifesting their catalytic activity. However, CaM has been suggested to control the transla...

Journal: :Molecular and cellular biology 2005
Sergio Di Marco Rachid Mazroui Patrice Dallaire Sridar Chittur Scott A Tenenbaum Danuta Radzioch Andre Marette Imed-Eddine Gallouzi

Muscle wasting (cachexia) is a consequence of chronic diseases, such as cancer, and is associated with degradation of muscle proteins such as MyoD. The cytokines tumor necrosis factor alpha and gamma interferon induce muscle degeneration by activating the transcription factor NF-kappaB and its target genes. Here, we show that a downstream target of NF-kappaB is the nitric oxide (NO) synthase ge...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Je-Seong Won Yeong-Bin Im Lyndon Key Inderjit Singh Avtar K Singh

In rat glial cells the lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) gene expression was enhanced by extracellular glucose concentration in a dose-dependent manner. On the other hand, 2-deoxy-d-glucose decreased the LPS-induced iNOS gene expression even in the presence of glucose (6 gm/l), suggesting that glucose metabolism is linked to the regulation of iNOS gene expr...

Journal: :Molecular human reproduction 1999
N Yoshiki T Kubota Y Matsumoto T Aso

The aim of the present study was to investigate the expression of mRNA and protein for inducible nitric oxide synthase (iNOS) in human cultured endometrial stromal cells. The endometrial stromal cells were cultured in the absence or the presence of cytokines such as interleukin (IL)-1beta and interferon (IFN)-gamma, which are inherently detectable in the endometrium. Nested reverse transcriptio...

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