For many years individual genetically controlled variation in the content of ABH and Lewis substance in human saliva has been recognized (Schiff & Sasaki, 1932; Grubb, 1948). A number of recent studies have suggested considerable variability in other constituents of human saliva. Thus, Kostlin & Rauch (1957), from the results of paper electrophoresis on human parotid and submandibular secretion...

Accumulating experimental evidence indicates that overexpression of the oncogenic receptor tyrosine kinase, Axl, plays a key role in the tumorigenesis and metastasis of various types of cancer. The objective of this study is to design a novel imaging probe based on the monoclonal antibody, h173, for microPET imaging of Axl expression in human lung cancer. A bifunctional chelator, DOTA, was conj...

OBJECTIVE The efficiency of HSV-tk/GCV system is not high because of insufficient gene transfer and incompletely initiative of host antineoplastic potency. The present study was designed to assess the antitumor efficacy of tk-MCP-1 on ovarian cancer in vitro and vivo. METHODS A novel bicistronic expression system can help to improve the expression level of a gene in a stable manner. pLXSN/tk-...

Purpose: Recent observations suggest that irradiation activates host immunologic response, resulting in potential clinical benefits. The aim of this study is to assess whether autoimmunity induced by stereotactic radiotherapy (SRT) has beneficial impacts on the treatment outcomes for metastatic breast cancer patients. Methods and Materials: Plasma serially corrected before, during, and after SR...

The epidermal growth factor receptor (EGFR) is one of the most comprehensively studied molecular targets in head and neck squamous cell carcinoma (HNSCC). However, inherent and acquired resistance are serious problems and are responsible for limited clinical efficacy and tumor recurrence. In this study, we evaluated the feasibility of immuno-positron emission tomography (PET) imaging and radioi...

Apolipoprotein B-48 (apoB-48) is produced by the small intestine, is associated with chylomicrons, and appears to be a suitable marker for clinical studies of postprandial dynamics of lipoproteins. It is also associated with cardiovascular risk factors. We have developed an assay system to quantify immuno-reactive apoB-48 in rabbit serum or plasma. A microtiter-plate was coated with monoclonal ...

20S proteasomes (prosomes/multicatalytic proteinase) are protein particles built of 28 subunits in variable composition. We studied the changes in proteasome subunit composition during the differentiation of U937 cells induced by phorbol-myristate-acetate or retinoic acid plus 1,25-dihydroxy-cholecalciferol by western blot, flow cytometry and immuno-fluoresence. p25K (C3), p27K (IOTA) and p30/3...