A high prevalence of sleep-disordered breathing (SDB) after spinal cord injury (SCI) has been reported in the literature; however, the underlying mechanisms are not well understood. We sought to determine the effect of the withdrawal of the wakefulness drive to breathe on the degree of hypoventilation in SCI patients and able-bodied controls. We studied 18 subjects with chronic cervical and tho...

An 8 month old Caucasian girl, with congenital central alveolar hypoventilation syndrome (Ondine's Curse), was discharged with her home ventilation managed by her parents. Her subsequent neurophysical development assessed at 22 months of age was satisfactory.

Corresponding E-Mail: [email protected] Clinical Perspectives R Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation (ROHHAD) is a devastating disorder that manifests in seemingly normal children, most typically between two and nine years of age. Because of the unique constellation of symptoms comprising the ROHHAD phenotype and inadequate public and...

The clinical course and changes in hypercapnic ventilatory drive over time were serially assessed before and after tracheostomy placement in a 14 year old, morbidly obese female patient with Prader-Willi syndrome, severe obstructive sleep apnoea, and obesity-hypoventilation syndrome. A tracheostomy became necessary after supplemental oxygen and continuous positive airway pressure (CPAP) had fai...

AIM The aim of the Danish National Database for Obstructive Sleep Apnea (NDOSA) was to evaluate the clinical quality (diagnostic, treatment, and management) for obstructive sleep apnea and obesity hypoventilation syndrome in Denmark using a real-time national database reporting to the Danish National Patient Registry. STUDY POPULATION All patients diagnosed with obstructive sleep apnea or obe...

dioxide on bronchoconstriction after pulmonary artery occlusion. Am J Physiol214: 772-775, 1968 33. Severinghaus JW, Stupfel MJ: Alveolar dead space as an index of distribution of blood flow in pulmonary capillaries. J Appl Physiol 10:335-348, 1957 34. Severinghaus JW, Swenson EW, Finley TN, Lategola MT, Williams J: Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. ...