OBJECTIVES Mineral trioxide aggregate (MTA) is extensively used in endodontics. However, MTA is difficult to handle because of its granular consistency, low mechanical properties and initial looseness. The objective of this study was to assess the compressive strength (CS), diametral tensile strength (DTS), and pH of set MTA using methyl cellulose as liquid. MATERIALS AND METHODS White ProRoo...

background: cellulite is the accumulation of subcutaneous fat and connective tissue in tights and buttocks. xanthines, such as aminophylline, are used as phosphodiesterase inhibitors, and are also adenosine receptor antagonists. objectives: the aim of the present study was to characterize in vitro aminophylline transdermal absorption through shed snake skin, and to investigate the absorption en...

In the present study sustained release matrix tablets of Theophylline were prepared by direct compression method using different grades and ratios of hydroxy propyl methyl cellulose in presence of ethyl cellulose to examine their influence on tablet properties and drug release profile. Theophylline is used to treat chronic obstructive pulmonary disease (COPD) and asthma. The drug has a narrow t...

Prostate cancer (PC) is the most frequently diagnosed disease in men in the United States. Curcumin (CUR), a natural diphenol, has shown potent anti-cancer efficacy in various types of cancers. However, suboptimal pharmacokinetics and poor bioavailability limit its effective use in cancer therapeutics. Several successful CUR nanoformulations have recently been reported which improve upon these ...

BACKGROUND Albendazole (ABZ) is a microtubule depolymerizing agent with a remarkable activity against a variety of tumor cells in vitro and in vivo. However, the lack of water solubility limits its application. Therefore, the aim of this study was to formulate ABZ with acetic acid/2-hydroxypropyl-β-cyclodextrin (HPβCD) with the view of improving its aqueous solubility and therefore, its antitum...

Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug delivery system (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipients to improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is an attempt to modulate the physicochemical properties of these cellulos...

this paper reviews the use of texture analysis in studying the performance of hydrophilic matrices of highly soluble drugs and different types of excipients (i.e. water-soluble, water-insoluble and swellable, and water insoluble and non-swellable). tablets were prepared by direct compression, and their swelling and erosion in presence of these different excipients were assessed with the help of...

The purpose of the present study was to formulate and evaluate Berberine HCl Film coated tablet. Preformulation studies API were done. film tablets have advantages over conventional oral dosage forms, tablet also influences release drug after compression. coating help in making with good taste masking properties excellent mechanical strength. It revealed that cellulosic materials unable resist ...

In this study, we have explored the slow (of the order of several hundreds of picoseconds) relaxation dynamics of water associated with the hydration shell of a biocompatible polymer, hydroxypropyl cellulose (HPC)-water mixture as a function of HPC concentration using time-resolved fluorescence spectroscopy. The relaxation dynamics slows down with a progressive increase in HPC content indicatin...

A series of 4alkyoxybenzoyloxypropyl cellulose (ABPC-n) samples was synthesized via the esterification of hydroxypropyl cellulose (HPC) with 4-alkoxybenzoic acid bearing different numbers of carbon atoms. The molecular structure of the ABPC-n was confirmed by Fourier transform infrared (FT-IR) spectroscopy and H NMR spectroscopy. The liquid crystalline (LC) phases and transitions behaviors were...