نتایج جستجو برای: hydrochlorothiazide

تعداد نتایج: 2020  

Journal: :The Journal of pharmacology and experimental therapeutics 2000
Y Uwai H Saito Y Hashimoto K I Inui

The renal tubular secretion of thiazides and loop diuretics via the organic anion transport system in renal tubules is required for them to reach their principal sites of action. Similarly, acetazolamide, a diuretic clinically administered for glaucoma, is excreted from the kidney by glomerular filtration and tubular secretion. In this study, we investigated the interaction and transport of the...

Journal: :Hypertension 1988
E L Bravo F M Fouad-Tarazi R C Tarazi M Pohl R W Gifford D G Vidt

Twenty-eight patients with resistant hypertension were found to have primary aldosteronism; 25 had solitary adenoma and 3 had adrenal hyperplasia. All were severely hypertensive despite receiving three or more antihypertensive agents, including conventional doses of diuretics, sympatholytics, and vasodilators. Hypervolemia (24 patients) or normovolemia (2 patients) despite severe diastolic hype...

Journal: :Hypertension 1990
M Martínez-Maldonado R Gely E Tapia J E Benabe

Diuretic therapy may enhance renin release by various mechanisms, principally contraction of extracellular fluid volume and its effects, including a fall in arterial pressure. Awake hydropenic or volume-expanded rats received diuretics (amiloride and hydrochlorothiazide) that are known inhibitors of NaCl transport beyond the macula densa; also the well-known Na(+)-K(+)-2 Cl- transport system in...

Journal: :Circulation 2007
Jürgen Scholze Elmar Grimm Dana Herrmann Thomas Unger Ulrich Kintscher

BACKGROUND Current guidelines for the treatment of hypertension do not provide specific recommendations for obese hypertensive patients. To identify an optimal treatment regimen for obese hypertensive patients, we studied the interactions between a drug-based weight loss approach by sibutramine and different antihypertensive drug regimens. METHODS AND RESULTS This was a prospective, 16-week d...

Journal: :Archives of internal medicine 2004
Peter W de Leeuw Luis M Ruilope Christopher R Palmer Morris J Brown Alain Castaigne Giuseppe Mancia Talma Rosenthal Gilbert Wagener

BACKGROUND Increasing evidence suggests renal involvement in hypertension-related cardiovascular and cerebrovascular complications. To assess this role of renal function in more detail, we studied the evolution of renal function and the relationship of renal function with mortality and morbidity in the Intervention as a Goal in Hypertension Treatment (INSIGHT) study. METHODS The INSIGHT study...

2009
Rhonda M. Cooper-DeHoff Sheron Wen Amber L. Beitelshees Issam Zineh John G. Gums Stephen T. Turner Yan Gong Karen Hall Vishal Parekh Arlene B. Chapman Eric Boerwinkle Julie A. Johnson

We assessed adverse metabolic effects of atenolol and hydrochlorothiazide among hypertensive patients with and without abdominal obesity using data from a randomized, open-label study of hypertensive patients without evidence of cardiovascular disease or diabetes mellitus. Intervention included randomization to 25 mg of hydrochlorothiazide or 100 mg of atenolol monotherapy followed by their com...

Journal: :Journal of clinical and diagnostic research : JCDR 2013
Suresh V Sagarad Sudha Biradar Kerure Chaitanya Kumar S Ramakrishna Mr

OBJECTIVE The primary objective of this study was to evaluate the antihypertensive efficacy of the chlorthalidone and telmisartan combination in Indian hypertensive patients who remained uncontrolled after taking the hydrochlorothiazide and telmisartan combination. METHODS A total of 100 eligible patients were enrolled in this prospective, open label study. The patients were given telmisartan...

Journal: :Archives of internal medicine 2001
P Sareli I V Radevski Z P Valtchanova E Libhaber G P Candy E Den Hond C Libhaber D Skudicky J G Wang J A Staessen

BACKGROUND Thiazides are recommended to initiate antihypertensive drug treatment in black subjects. OBJECTIVE To test the efficacy of this recommendation in a South African black cohort. METHODS Men and women (N = 409), aged 18 to 70 years, with a mean ambulatory daytime diastolic blood pressure between 90 and 114 mm Hg, were randomized to 13 months of open-label treatment starting with the...

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