BACKGROUND Previous studies have suggested the existence of enteropathy in cystic fibrosis (CF), which may contribute to intestinal function impairment, a poor nutritional status and decline in lung function. This study evaluated enterocyte damage and intestinal inflammation in CF and studied its associations with nutritional status, CF-related morbidities such as impaired lung function and dia...

PURPOSE This study aimed to determine Cu/Zn ratio, nutritional and inflammatory status in patients during the perioperative period for colorectal cancer. METHODS The study included patients with histological diagnosis of colorectal adenocarcinoma (Cancer Group, n=46) and healthy volunteers (Control Group, n=28). We determined habitual food intake, body composition, laboratory data of nutritio...

PURPOSE Small intestinal function returns first after surgery, and then the function of the stomach returns to normal after postoperative ileus (POI). The aim of this study was to investigate inflammatory responses in the muscle coat of stomach and small intestine in guinea pig POI model. MATERIALS AND METHODS The distance of charcoal migration from pylorus to the distal intestine was measure...

Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. The cardinal pathogenic factors include increased sebum secretion, follicular hyperkeratinization and microbial colonization by Cutibacterium acnes. Calprotectin released from activated neutrophils, can be detected in serum or other body fluids. Aim: aim present study was to clarify if calprotectin plays rol...

The cytokine IL-22 plays a critical role in mucosal barrier defense, but the mechanisms that promote IL-22 expression in the human intestine remain poorly understood. As human microbe-responsive Vγ9/Vδ2 T cells are abundant in the gut and recognize microbiota-associated metabolites, we assessed their potential to induce IL-22 expression by intestinal CD4+ T cells. Vγ9/Vδ2 T cells with character...

Editorial Fecal calprotectin: towards a standardized use for inflammatory bowel disease management in routine practice. The measurement of fecal calprotectin has now been studied in clinical research for more than 10 years. Its ability to differentiate Inflammatory bowel disease (IBD) from irritable bowel syndrome (IBS) patients and to predict clinical relapse in patients with Crohn's disease o...

Introduction The cytoplasmic S100 proteins derived from cells of myeloid origin. Calprotectin (MRP8/14 protein complex) might be a biomarker either for autoinflammation and autoimmunopathy. Since autoinflammatory diseases might be a diagnostic challenge calprotectin may be helpful in the diagnosis of autoinflammatory diseases. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory, non...

Introduction The cytoplasmic S100 proteins derived from cells of myeloid origin. Calprotectin (MRP8/14 protein complex) might be a biomarker either for autoinflammation and autoimmunopathy. Since autoinflammatory diseases might be a diagnostic challenge calprotectin may be helpful in the diagnosis of autoinflammatory diseases. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory, non...