BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis. METHODS Data from 2,445 subjects (51.7% females) aged 18 to 65 years participating ...

Recent evidence has demonstrated additional roles for the neuronal guidance protein receptor UNC5B outside the nervous system. Given the fact that ischemia reperfusion injury (IRI) of the liver is a common source of liver dysfunction and the role of UNC5B during an acute inflammatory response we investigated the role of UNC5B on acute hepatic IRI. We report here that UNC5B(+/-) mice display red...

Hepatic disease is usual in large animals. Increases in serum hepatic enzymes and total bile acid concentration may indicate hepatic dysfunction, insult, disease, or failure. While liver disease is particularlyusual in foals, progression to liver failure isn't.Diseases that frequently result in hepatic failure in horses include Theiler's disease, Tyzzer's disease, pyrrolizidine alkaloid toxicos...

Intestinal ischemia-reperfusion (I/R) injury causes severe illness frequently complicated by remote multiorgan dysfunction and sepsis. Recent studies implicated interleukin-17A (IL-17A) in regulating inflammation, autoimmunity, and I/R injury. Here, we determined whether IL-17A is critical for generation of intestinal I/R injury and subsequent liver and kidney injury. Mice subjected to 30 min o...

Background and objectives: Acetaminophen (APAP) is a common analgesic medicine whose overdose leads to severe hepatic dysfunction. Due to the known antioxidant properties of Alliumspecies, the present study aimed to evaluate the protective effects of Allium saralicum plant on APAP induced liver toxicity. Methods: The hydro-alcoholic e...

PURPOSE To identify the correlation of the model for end-stage liver disease (MELD) scores with the assessment of the risk of hepatic function after hemihepatectomy in patients with hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV). METHODS A case-control study was performed based on data for 141 consecutive patients who underwent curative right hepatic resection between Janua...

the purpose of this study was to determine a simple and sensitive test for clinical diagnosis of various hepatic diseases. therefore y-glutamyltranspeptidase (y** gt), aspartate aminotransferase (asat), alanine aminotr¬ansferase (alat) and alkaline phosphatase (alp) levels were measured in 29 healthy adults and 88 sera with various liver diseases. table i represents the results, according to wh...

wasp sting is a relatively common arthropod assault. this usually results in pain and mild allergic reactions, but sometimes may cause severe systemic reaction and multiorgan dysfunction including rhabdomyolysis, hemolysis, coagulopathy, hepatic, renal and cardiac complications. along with several other pathomechanisms, rhabdomyolysis is a distinguished cause of acute kidney injury (aki) in pat...

BACKGROUND Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting. Further, these patients are often not candidates for other anti-cancer therapies, highlighting their need for active treatment options. MET...

Dysfunction of hepatic insulin receptor tyrosine kinase (IRTK) causes the development of type 2 diabetes. However, the molecular mechanism regulating IRTK activity in the liver remains poorly understood. Here, we show that phosphoinositide 3-kinase enhancer A (PIKE-A) is a new insulin-dependent enhancer of hepatic IRTK. Liver-specific Pike-knockout (LPKO) mice display glucose intolerance with i...