نتایج جستجو برای: hemophagocytosis
تعداد نتایج: 441 فیلتر نتایج به سال:
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by severe hyperinflammation due to an overwhelming ineffective immune response to different triggers. Most important symptoms are fever, hepatosplenomegaly and cytopenias. Biochemical signs include elevated ferritin, hypertriglyceridemia and low fibrinogen. Hemophagocytosis in the bone marrow is a hallmark of this syndrome. Ba...
Results We report a case of an infant, 1 year and 8 months old, male, that was in intensive care unit for five months with initial diagnosis of acute diarrhea, dehydration and hemolytic uremic syndrome. The infant developed fever, hepatosplenomegaly, cutaneous rash, bicytopenia, elevated serum ferritin, liver enzyme abnormalities, encephalitis, acute renal failure and serum hypogammaglobulinemi...
A 16-year-old boy with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (HLH) underwent allogeneic hematopoietic stem cell transplantation after conditioning with fludarabine, melphalan, total body irradiation, and rabbit antithymocyte globulin (ATG). A severe, persistent infusion reaction occurred after the initial administration of ATG. Investigations showed a rapid increase i...
with a specific myeloma immunoglobulin type, although a more aggressive course is observed in light-chain-only subtypes [10]. Requena et al. [11] analyzed 8 cases of cutaneous plasmacytoma and revealed that malignant plasmacytes are homogeneous in their immunophenotype with strong expression of CD79a, CD138, and epithelial membrane antigen. In addition, RB1 gene deletion in skin-infiltrated pla...
Infection associated hemophagocytosis may result from immunologic activation of mononuclear phagocyte system. The phenomenon of HP may affect various organ functions and hematological parameters. Exaggerated HP can lead to HPS which is a fatal condition. Recognizing and treating this disorder (anticytokine therapy) and underlying infection may save the life of the patient. The aim of the presen...
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