Despite use of similar drugs, outcomes of recent heart failure (HF) trials were frequently neutral in heart failure with normal left ventricular ejection fraction (HFNEF) and positive in heart failure with reduced left ventricular ejection fraction (HFREF). The neutral outcomes of HFNEF trials were often attributed to deficient HFNEF patient recruitment with inclusion of many HFREF or noncardia...

AIMS The Home or Hospital in Heart failure (HHH) study was a European Community-funded, multinational, randomized controlled clinical trial, conducted in the UK, Poland, and Italy, to assess the feasibility of a new system of home telemonitoring (HT). The HT system was used to monitor clinical and physiological parameters, and its effectiveness (compared with usual care) in reducing cardiac eve...

Although approximately 260,000 persons die annually in the United States (USA) with heart failure (HF), HF patients infrequently receive hospice care. Patients with refractory symptoms of HF at rest despite optimal medical therapy (Stage D) have less than a one-year survival1,2 and American Heart Association/American College of Cardiology guidelines recommend hospice care as an option for this ...

More successful recognition and treatment of cardiovascular risk factors and diseases continues to decrease mortality and increase the proportion of elderly population. Therefore, there are more people with increased risk of developing heart failure and atrial fibrillation in the course of their lives. Atrial fibrillation (AF) can complicate the course of congestive heart failure (HF) leading t...

Obesity adversely affects many cardiovascular disease (CVD) risk factors and increases the risk of most CVD, including heart failure (HF). HF is markedly increased in the setting of obesity. However, obese patients with HF have a better prognosis than lean patients with HF, which has been termed the obesity paradox. Therefore, the role of weight loss, which generally improves ventricular struct...

Exercise training is a well-known coadjuvant in heart failure treatment; however, the molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary cause, heart failure is often preceded by two distinct phenomena: mitochondria dysfunction and cytosolic protein quality control disruption. The objective of the study was to determine the contribution of exercise traini...

This literature review reflects modern ideas about the combination of heart failure (HF) and osteoporosis, common risk factors for these diseases, pathophysiological mechanisms metabolic bone diseases in HF. Despite a growing number studies on combined cardiovascular skeletal system pathology, relationship between decrease mineral density HF remains poorly understood. Both conditions are causes...

Heart failure (HF) is a syndrome with a broad spectrum of heterogeneous symptoms and signs resulting in a wide range of clinical expressions. The prevalence of HF is estimated to be 1-2% in developed countries, increasing with age. Heart failure is the leading cause of hospitalization for patients older than 65 years, raising concerns about the economic burden of this syndrome. This article pro...

AIM The objective was to evaluate in treated heart failure (HF) patients whether multidrug therapy interferes with the cardiovascular autonomic response to postural stress. METHODS AND RESULTS Blood pressure (BP; Finapres), heart rate (HR), stroke volume, and total peripheral resistance (TPR) responses to standing up were measured in 33 HF patients and 10 healthy age-matched controls. Ten hyp...