objectives the present study aimed to evaluate the genotypes and prevalence of mutations in a segment of s and rt gene in hbv isolates in southern khorasan, iran. methods this was a population-based study comprising 5,235 randomized samples for hbv screening. a nested-polymerase chain reaction (pcr) test was followed by direct sequencing, and the sequences blast with present sequences of ncbi d...

Abstract Background Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma, and showed the host genetic factors play an important role in these HBV-related outcomes. Methods Collected samples from different outcomes infection performed genotyping by Affymetrix 500 k SNP Array. GCTA tool, PLINK, Bonferroni method were ...

objective: gbv-c is a virus transmissible via blood transfusion and sexual routes. because of the shared transmission routes in gbv-c and hepatitis b virus (hbv) we have attempted to detect gbv-c in hbsag-positive patients using the more sensitive semi-nested pcr. we used restriction fragment length polymorphism (rflp) to determine genotype. methods: a total of 100 serum samples were collected...

We read with great interest the recent article published by Mercier et al. (4) on the overestimation of mixed infections as a result of erroneous genotype H detection by use of the new version of the INNO-LiPA HBV genotyping assay. In this study, the INNO-LiPA assay identified 28 mixed infections in a population of 200 HBsAgand anti-HBcAg-hepatitis B virus (HBV)-DNA-positive French blood donors...

TO THE EDITOR—We read with interest the article by Chun et al [1]. They demonstrated the negative impact of chronic hepatitis B virus (HBV) coinfection on HIV progression by increasing the risk for AIDS-defining illness and death (adjusted hazard ratio [aHR], 1.80; 95% confidence interval [CI], 1.20–2.69) among 2352 HIV-infected active duty military personnel and other beneficiaries in whom the...

HBV genome is of approximately 3,200 base pairs having partially circular duplex DNA molecule. The circularity of HBV DNA is maintained by 5’ cohesive ends. The mRNA is synthesized by negative DNA strand of HBV. Four overlapping open reading frames are present *Corresponding author: Javed Iqbal, School of Life Sciences, Shaanxi Normal University, Xian, P.R China, Tel: (+52) 477-2674900; E-mail:...

Hepatitis B virus (HBV) prevalence is highest in Sub-Saharan Africa including Ethiopia. HBV genotypes have distinct geographic distributions and play a role in course of infection and treatment management. However, in Ethiopia there is paucity of information about distribution of HBV genotypes. This study was done to determine genotype, mutation and sero-virological profiles of HBV isolates in ...

Introduction: Occurrence of detectable amounts of viral antigen or viral particles in the blood of infected patients with Hepatitis B virus (HBV) is a significant characteristic of HBV infection. Detection of HBV antigen or its DNA among individuals of a community is a crucial factor to know the burden of HBV infection. Hepatitis B surface antigen (HBsAg) is a suitable marker of HBV infection b...