BACKGROUND Cervical cancer is one of the most common causes of cancer mortality among women worldwide, but actually is largely preventable. The practice of Pap smear testing (PST) needs to be expanded in order to diagnose cervical cancer at an early stage and thus reduce the burden this women's health problem brings to the society. Effective public education is therefore crucial. Determining th...

The treatment of advanced gynecologic cancers remains palliative in most of cases. Although systemic treatment has entered into the era of targeted drugs the antitumor efficacies of current therapies are still limited. In this context there is a great need for more active treatment and rationally designed targeted therapies. The PI3K/AKT/mTOR is a signaling pathway in mammal cells that coordina...

Abstract Debulking surgery, also called cytoreductive is a resection of the tumor as much possible and an intended incomplete for unresectable malignant tumors. Since most important principle in surgical oncology complete R0 resection, debulking surgery goes against basic obscures concept operability. However, has been advocated various types advanced tumors, including gynecological cancers, ur...

Background. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. It is typically associated with upper aerodigestive tract malignancies in mal...

Cell-cell interaction is important in the expansion of leukemic cells and of solid tumors. Steel factor (SF) or Kit ligand is produced as a membrane-bound form (mSF) and a soluble form. Because both primary gynecological tumors and primary leukemic cells from patients with acute myeloblastic leukemia (AML) have been shown to coexpress c-Kit and SF, we addressed the question of whether mSF could...

ARID1A encodes a key component of the SWI–SNF chromatin remodeling complex, participating in control PI3K/AKT/mTOR pathway. No data are available for patient populations whose tumors harbor multiple mutations. A variety compounds being tested ARID1A-altered cancers, without any drug approval so far. Molecular and clinical characteristics patients evaluated at Phase I Unit Fondazione Policlinico...

Background: Peritoneal metastases (PM) are a common manifestation of gastro-intestinal and gynecological cancers. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has been proposed as new drug delivery technique to treat patients with PM. During this procedure, CO2 pneumoperitoneum (12 mmHg) is established. Subsequently, nebulizer (Capnopen®, Zimmern, Germany) aerosolizes the chemothera...

We report on a rare case of paraneoplastic syndrome (PS) that was discovered completion diagnostic work up to be fallopian tube carcinoma. A 65year old female, presented with 1 month history imbalance, gait instability, incoordination right upper limb, vertigo and vomiting. Cerebrovascular accident drug intoxication excluded. Indicative further diagnosis presence adnexal mass in pelvis identifi...

Toll-like receptor 4 (TLR4) is a member of the TLR family. Members of the TLR family play an important role in innate immune responses and are induced by recognition of pathogenassociated molecular patterns. They are also involved in cell proliferation and apoptosis in cancer. We investigated the role of TLR4 in apoptotic cell death in gynecological cancer cells; gynecological cancer is associa...