نتایج جستجو برای: glycyrrhetinic acid
تعداد نتایج: 747450 فیلتر نتایج به سال:
We investigated the inhibitory effect of three glycyrrhizin derivatives, such as Glycyrrhizin (compound 1), dipotassium glycyrrhizate (compound 2) and glycyrrhetinic acid (compound 3), on the activity of mammalian pols. Among these derivatives, compound 3 was the strongest inhibitor of mammalian pols α, β, κ, and λ, which belong to the B, A, Y, and X families of pols, respectively, whereas comp...
Licorice (glycyrrhiza root) has been used as a herbal medicine worldwide with its main active constituent being glycyrrhizin (GL). Licorice sometimes causes adverse effects such as inducing pseudoaldosteronism by inhibiting type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) caused by glycyrrhetinic acid (GA), a major metabolite of GL. In this study we compared the inhibitory effects of GA, GL, ...
In several tissues, transient receptor potential vanilloid 4 (TRPV4) channels are involved in the response to hyposmotic challenge. Here we report TRPV4 protein in porcine lens epithelium and show that TRPV4 activation is an important step in the response of the lens to hyposmotic stress. Hyposmotic solution (200 mosM) elicited ATP release from intact lenses and TRPV4 antagonists HC 067047 and ...
Antiviral activities of <i>Glycyrrhiza uralensis</i> components against Singapore grouper iridovirus
Singapore grouper iridovirus (SGIV) is a serious pathogen that negatively impacts aquaculture. Because of its 90% fatality rate, effective medications control SGIV infection are urgently needed. Glycyrrhiza uralensis well-known medicinal plant contains active ingredients with antiviral, antibacterial, and other biological activities. In this study, we evaluated the application G. components aga...
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