نتایج جستجو برای: genomic targeted therapy
تعداد نتایج: 883589 فیلتر نتایج به سال:
Gene therapy for HIV (human immunodeficiency virus) involves the introduction of a therapeutic gene into the infected individual for the purposes of reducing viral load and ultimately reconstituting a healthy immune system. Clinical trials for HIV gene therapy have not yet reported therapeutic benefit. In addition to improving the efficiency of gene delivery and the maintenance of gene expressi...
UNLABELLED How genomic heterogeneity associated with acquired resistance to targeted agents affects response to subsequent therapy is unknown. We studied EGFR blockade in colorectal cancer to assess whether tissue and liquid biopsies can be integrated with radiologic imaging to monitor the impact of individual oncogenic alterations on lesion-specific responses. Biopsy of a patient's progressing...
PURPOSE The purpose of this study was to develop an integrated genomic-based approach to personalized treatment of patients with advanced-stage ovarian cancer. We have used gene expression profiles to identify patients likely to be resistant to primary platinum-based chemotherapy and also to identify alternate targeted therapeutic options for patients with de novo platinum-resistant disease. ...
This paper discusses the role of peptides in cancer therapy with special emphasis on peptide drugs which are already approved and those in clinical trials. The potential of peptides in cancer treatment is evident from a variety of different strategies that are available to address the progression of tumor growth and propagation of the disease. Use of peptides that can directly target cancer cel...
BACKGROUND Genome editors such as CRISPR/Cas9 and TALENs are at the forefront of research into methodologies for targeted modification of the mammalian genome. To date few comparative studies have been carried out to investigate the difference of genome editing characteristics between CRISPR/Cas9 and TALENs. While the CRISPR/Cas9 system has overtaken TALENs as the tool of choice for most resear...
Breast cancer (BCa) is one of the leading health problems among women. Although significant achievements have led to advanced therapeutic success with targeted therapy options, more efforts are required for different subtypes tumors and according genomic, transcriptomic, proteomic alterations. This study underlines role microRNA-21 (miR-21) in metastatic MDA-MB-231 breast cells. Following knock...
Abstract Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety efficacy of doublet CDK4/6 inhibitor palbociclib plus selective taselisib advanced solid tumors, triplet fulvestrant 25 patients with PIK3CA-mutant, cancer. The therapy response rate was 37.5% [95% con...
The rate of colorectal cancer (CRC) has altered. Early-onset CRC patients are increasing, and it is one the main causes cancer-related death. Based on epidemiologic change, screening program needs to be changed. To increase compliance, non-invasive techniques developed. Although survival increased, oncologic prognosis metastatic remains poor. Even in CRC, which most difficult treat, attempts be...
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