For years, studies of founder populations and genetic isolates represented the mainstream of genetic mapping in the effort to target genetic defects causing Mendelian disorders. The genetic homogeneity of such populations as well as relatively homogeneous environmental exposures were also seen as primary advantages in studies of genetic susceptibility loci that underlie complex diseases. Europe...

Genealogical data have been used very widely to construct indices with which to examine the contribution of plant breeding programmes to the maintenance and enhancement of genetic resources. In this paper we use such indices to examine changes in the genetic diversity of the winter wheat crop in England and Wales between 1923 and 1995. We find that, except for one period characterized by the do...

Different structural features of human language change at different rates and thus exhibit different temporal stabilities. Existing methods of linguistic stability estimation depend upon the prior genealogical classification of the world’s languages into language families; these methods result in unreliable stability estimates for features which are sensitive to horizontal transfer between fami...

The present paper argues for a more complete integration between recent „genealogical‟ approaches to the problem of knowledge and evolutionary accounts of the development of human cognitive capacities and practices. A structural tension is pointed out between, on the one hand, the fact that the explicandum of genealogical stories is a specifically human trait and, on the other hand, the tacit a...

1 are to be congratulated on their research of the autosomal dominant Stargardt disease gene (STGD3). This study contains some extremely complex issues that require some clarification , as well as some basic and simple findings that should be emphasized. The basic issues center on gene-alogy, phenotype classification (lumping vs splitting), genotype and haplotype analysis, and statistics. Since...

Pivot relies on DeepZoom (Microsoft’s technology formerly known as SeaDragon: http://zoom.it/) to provide a smooth zooming experience. For the Silverlight PivotView experience this is done with the built-in MultiScaleImage control. Because of this, the images for a Pivot collection are stored in the Deep Zoom hierarchical tile file structure. This consists of a root-level XML file (usually with...