This article is linked to Kuo et al and Camilleri & papers. To view these articles, visit https://doi.org/10.1111/apt.16451 https://doi.org/10.1111/apt.16475 There an urgent need for safe effective pharmacotherapy in gastroparesis, a debilitating condition estimated affect 13.8 per 100 000 persons the United Kingdom.1 Adults with gastroparesis are recognised suffer from repeated hospitalisation...

provided the original work is properly cited. CC Diabetic gastroparesis is characterized by delayed gastric emptying, which stems from long-standing diabetic neuromyopathy. The symptoms of gastroparesis include early satiety, nausea, vomiting, postprandial fullness and upper abdominal pain [1]. Here, we present the case of a patient with a 20-year history of diabetes mellitus and a 2-year histo...

Background Gastrointestinal (GI) complications such as constipation, diarrhea and gastroparesis are common in hereditary transthyretin (ATTR) amyloidosis. The mechanisms behind these disturbances have not been fully elucidated and the patients’ small bowel function remains largely unexplored. The aim of the present study was to compare the small bowel motility in patients with hereditary ATTR a...

Complications due to aspiration of barium contrast occur rarely during studies the digestive tract. While lung tissue can tolerate small amounts Barium large quantities exceed lung’s capacity and consequently lead death especially, in geriatric patients. affect pulmonary ventilation perfusion function, causing dyspnoea, hypoxemia respiratory failure. We herein report a swallow case which an 82-...

UNLABELLED The medical literature states that solid gastric-emptying studies are more sensitive for the detection of gastroparesis than are liquid studies; thus, liquid studies are rarely required. However, we have seen patients with normal solid but delayed liquid emptying. The purpose of this investigation was to determine whether a study of clear liquid gastric emptying has added value for t...

References 1. McCann LJ, Juggins AD, Maillard SM, Wedderburn LR, Davidson JE, Murray KJ, Pilkington CA: Juvenile Dermatomyositis Research Group. The Juvenile Dermatomyositis National Registry and Repository (UK and Ireland)–clinical characteristics of children recruited within the first 5 yr. Rheumatology 2006, 45(10):1255-1260. 2. Laskin BL, Choyke P, Keenan GF, Miller FW, Rider LG: Novel gast...

While aspiration and feeding difficulties are well known challenges in the intensive care unit, their pathophysiology has been poorly understood. New information suggests that the critically ill are subject to profound alterations in motor and sensory function of the oesophagus, lower oesophageal sphincter, stomach, and duodenum which go some way to explaining their propensity to reflux and gas...