The aim of the present research was to make a comparison between two Bulgarian commercial forms of Rosa canina L. for herbal preparations in terms of the possible benefits by oral intake. The plant samples were investigated for their antioxidant activity and the bioactive substances. The total phenolic content of the extracts was evaluated as well. Four reliable methods (DPPH, ABTS, FRAP and CU...

Two studies in healthy subjects assessed the absorption of edoxaban when delivered to specific locations within the gastrointestinal tract using Enterion capsules. In study 1 (single-dose, 4-way crossover), 8 participants received edoxaban 60 mg as immediate-release (IR) tablets (treatment A), as powder formulation delivered to the distal small bowel (treatment B) or ascending colon (treatment ...

The implication of organic acids in Cd and Ni translocation was studied in the halophyte species Sesuvium portulacastrum. Citric, fumaric, malic, and ascorbic acids were separated and quantified by HPLC technique in shoots, roots and xylem saps of plants grown on nutrient solutions added with 50 μM Cd, 100 μM Ni and the combination of 50 μM Cd + 100 μM Ni. Results showed that Cd had no signific...

Dimethyl fumarate (DMF) is approved for disease-modifying treatment of patients with relapsing-remitting multiple sclerosis. Animal experiments suggested that part of its therapeutic effect is due to a reduction of T-cell infiltration of the central nervous system (CNS) by uncertain mechanisms. Here we evaluated whether DMF and its primary metabolite monomethyl fumarate (MMF) modulate pro-infla...

BACKGROUND Sarcoidosis is a multisystem disease of unknown origin characterized by the formation of noncaseating granulomas, in particular in the lungs, lymph nodes, eyes, and skin. Systemic treatment for cutaneous sarcoidosis can be used for large disfiguring lesions, generalized involvement, or recalcitrant lesions that did not respond to topical therapy. CASE PRESENTATIONS We report three ...

Fumaric Acid Esters (FAE) are found naturally in some plants (Fumaria officinalis) and mushrooms. In Germany, a mixture of fumaric acid esters (Fumaderm®) is licensed for the treatment of psoriasis [1]. A clinical formulation of dimethyl fumarate (referred to as gastro-resistant Dimethyl Fumarate (DMF) or delayed-release DMF) is approved in the United States, New Zealand, Australia, European Un...

Inflammation and oxidative stress have been implicated in the pathogenesis of metabolic disturbances. Esters of fumaric acid, mainly dimethyl fumarate, exhibit immunomodulatory, anti-inflammatory, and anti-oxidative effects. In the current study, we tested the hypothesis that fumaric acid ester (FAE) treatment of an animal model of inflammation and metabolic syndrome, the spontaneously hyperten...

The treatment of ICR mice with i.p. injections (0.14 g/kg/day) of the extract of Capsella bursa-pastoris herb (Cruciferae) caused 50 to 80% inhibition of the solid growth of Ehrlich tumor cells that had been inoculated into the s.c. tissue of the animals. The tumor lumps in the treated mice showed multifocal necroses and the infiltartion of host fibrous tissue cells. Experiments were also perfo...