The Report of the Committee of Inquiry into Human Fertilisation and Embryology, commonly called the Warnock Report after the chair of the committee Mary Warnock, is the 1984 publication of a UK governmental inquiry into the social impacts of infertility [4] treatment and embryological research. The birth of Louise Brown in 1978 in Oldham, UK, sparked debate about reproductive and embryological ...

The Report of the Committee of Inquiry into Human Fertilisation and Embryology, commonly called the Warnock Report after the chair of the committee Mary Warnock, is the 1984 publication of a UK governmental inquiry into the social impacts of infertility [4] treatment and embryological research. The birth of Louise Brown in 1978 in Oldham, UK, sparked debate about reproductive and embryological ...

We report two families in which neonatal haemochromatosis was observed in half sibs. In the first family, two successive girls were born of different fathers. In the second family, an affected brother and sister were followed by an affected half brother born after donor insemination. These observations, as well as a previous abstract describing two affected half sisters, revive the debate over ...

The Report of the Committee of Inquiry into Human Fertilisation and Embryology, commonly called the Warnock Report after the chair of the committee Mary Warnock, is the 1984 publication of a UK governmental inquiry into the social impacts of infertility [4] treatment and embryological research. The birth of Louise Brown in 1978 in Oldham, UK, sparked debate about reproductive and embryological ...

Upon fertilisation by sperm, mammalian eggs are activated by a series of intracellular Ca(2+) oscillations that are essential for embryo development. The mechanism by which sperm induces this complex signalling phenomenon is unknown. One proposal is that the sperm introduces an exclusive cytosolic factor into the egg that elicits serial Ca(2+) release. The 'sperm factor' hypothesis has not been...

The new CPEM (cooked potato effective mass) method was used to study the sloughing of a potato variety grown in two successive years in six regimes given by different levels and forms of fertilisation and irrigation. The sloughing process is characterized by the cooking time, i.e. the starting point of disintegration, and by the speed of disintegration. Both parameters are also evaluated in dep...

Essential hypertension remains poorly understood, despite the enormous efforts of research, which brought understanding of certain physiopathological and treat­ ment mechanisms. New insights have emerged from recent data showing that environmental insults during (in vitro) fertilisation, foetal, perinatal and childhood periods may lead to vascular dysfunction and hyper­ tension later in life (t...

Cryogenic storage of sperm from genetically altered Xenopus improves cost effectiveness and animal welfare associated with their use in research; currently it is routine for X. tropicalis but not reliable for X. laevis. Here we compare directly the three published protocols for Xenopus sperm freeze-thaw and determine whether sperm storage temperature, method of testes maceration and delays in t...

Intracytoplasmic sperm injection (ICSI) is a promising assisted-fertilisation technique that may benefit women who have not become pregnant by in-vitro fertilisation (IVF) or subzonal insemination (SUZI) of oocytes. We have used ICSI to treat couples with infertility because of severely impaired sperm characteristics, and in whom IVF and SUZI had failed. Direct injection of a single spermatozoo...

Silver Russell Syndrome (SRS) is a rare condition (1/3000 - 1/100,000 newborns). We present a female infant with SRS, cardiac malposition and asymmetric enlargement of the clitoris. She is the first child of Greek nonconsanguinous parents, born at 38 weeks gestation, following in vitro fertilisation (IVF). The patient had intrauterine growth retardation, body asymmetry, enlarged clitoris, hemih...