نتایج جستجو برای: fatty acid elongase gene

تعداد نتایج: 1796572  

2015
Rafat A. Siddiqui Zhidong Xu Kevin A. Harvey Thomas M. Pavlina Michael J. Becker Gary P. Zaloga

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries. NAFLD encompasses a spectrum of diseases, ranging from hepatic steatosis to non-alcoholic steatohepatitis (NASH), cirrhosis, and liver failure. The etiology of NAFLD remains unclear but is thought to relate to increased fatty acid flux within the liver that results in t...

Journal: :Plant biotechnology journal 2007
Elzbieta Mietkiewska Jennifer M Brost E Michael Giblin Dennis L Barton David C Taylor

A genomic fatty acid elongation 1 (FAE1) clone was isolated from Crambe abyssinica. The genomic clone corresponds to a 1521-bp open reading frame, which encodes a protein of 507 amino acids. In yeast cells expression of CrFAE led to production of new very long chain monounsaturated fatty acids such as eicosenoic (20:1(delta11)) and erucic (22:1(delta13)) acids. Seed-specific expression in Arabi...

Journal: :Journal of animal science 2014
S K Duckett S L Pratt

Anabolic implants are routinely used in the finishing phase of beef production to improve animal performance and feed efficiency. Implanting during the feedlot phase on average increases ADG 18%, feed intake 6%, feed efficiency 8%, carcass weight 5%, and ribeye area 4% compared with nonimplanted controls. Implants reduce the cost of beef production, which is important given current high feed co...

2017
Si Chen Hua He Xiaolin Liu

In mammals, very long chain fatty acids (VLCFAs) perform pleiotropic roles in a wide range of biological processes, such as cell membrane formation, cell signal transduction, and endocrine regulation. Beef and milk are abundant of palmitic acid which can be further elongated into stearic acid for synthesizing VLCFAs. Elongase of very long chain fatty acid 6 (ELOVL6) is a rate-limiting enzyme fo...

2014
Samuel P. Hoile Rebecca Clarke-Harris Rae-Chi Huang Philip C. Calder Trevor A. Mori Lawrence J. Beilin Karen A. Lillycrop Graham C. Burdge Wolf-Hagen Schunck

BACKGROUND Studies in animal models and in cultured cells have shown that fatty acids can induce alterations in the DNA methylation of specific genes. There have been no studies of the effects of fatty acid supplementation on the epigenetic regulation of genes in adult humans. METHODS AND RESULTS We investigated the effect of supplementing renal patients with 4 g daily of either n-3 long-chai...

Journal: :Investigative ophthalmology & visual science 2003
Pamela S Lagali Jiafan Liu Rajesh Ambasudhan Laura E Kakuk Steven L Bernstein Gail M Seigel Paul W Wong Radha Ayyagari

PURPOSE The gene elongation of very long chain fatty acids-4 (ELOVL4) has been shown to underlie phenotypically heterogeneous forms of autosomal dominant macular degeneration. In this study, the extent of evolutionary conservation and the existence and localization of retinal expression of this gene was investigated across a wide variety of species. METHODS Southern blot analysis of genomic D...

2017
Franck Chiappini Audrey Coilly Hanane Kadar Philippe Gual Albert Tran Christophe Desterke Didier Samuel Jean-Charles Duclos-Vallée David Touboul Justine Bertrand-Michel Alain Brunelle Catherine Guettier François Le Naour

Nonalcoholic steatohepatitis (NASH) is a condition which can progress to cirrhosis and hepatocellular carcinoma. Markers for NASH diagnosis are still lacking. We performed a comprehensive lipidomic analysis on human liver biopsies including normal liver, nonalcoholic fatty liver and NASH. Random forests-based machine learning approach allowed characterizing a signature of 32 lipids discriminati...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید