Insulator sequences help to organize the genome into discrete functional regions by preventing inappropriate cross-regulation. This is thought to be mediated in part through associations with other insulators located elsewhere in the genome. Enhancers that normally drive Drosophila even skipped (eve) expression are located closer to the TER94 transcription start site than to that of eve. We dis...

Client emulation tools play a central role in the performance evaluation, capacity planning, and workload characterization of servers. However, traditional emulation tools, because of their limited scalability and extensibility, fail to keep up with servers as they increase in complexity and performance. In this paper, we propose Eve, a scalable client emulation tool that is capable of stress-t...

BOSTON (AP) Sen. Edward M. Kennedy campaigned in the precincts of his political youth * yesterday, telling Massachu­ setts voters “ 1 have come home to ask for your help” to rekindle his flickering challenge to Pres­ ident Carter. R epublican G eorge Bush sought a comeback against Ronald Reagan and said he was making election-eve headway. For Bush as for Kennedy, the Massachusetts presidential ...

Adamalysins [a disintegrin and metalloproteinase (ADAM)] are a family of cell surface transmembrane proteins that have broad biological functions encompassing proteolysis, adhesion, and cell signal regulation. We previously showed that the cytoplasmic domain of ADAM-15 interacts with Src family protein tyrosine kinases and the adaptor protein growth factor receptor binding protein 2 (Grb2). In ...

We consider an initial Eve-population and a population of neutral mutants, such that the total population dies out in finite time. We describe the evolution of the Eve-population and the total population with continuous state branching processes, and the neutral mutation procedure can be seen as an immigration process with intensity proportional to the size of the population. First we establish...

OBJECTIVE To examine the expression of ADAM-10 in rheumatoid arthritis (RA) synovial tissue (ST) and the role it plays in angiogenesis. METHODS ADAM-10 expression was determined using immunohistology, Western blotting, and quantitative polymerase chain reaction. In order to examine the role of ADAM-10 in angiogenesis, we performed in vitro Matrigel tube formation and chemotaxis assays using h...

This paper presents Eve, a new ExecuteVerify architecture that allows state machine replication to scale to multi-core servers. Eve departs from the traditional agree-execute architecture of state machine replication: replicas first concurrently and nondeterministically execute requests; then they verify, agree, and converge on the state and the outputs produced by a correct replica. Eve minimi...

Asthma is a complex disease linked to various pathophysiological events including the activity of proteinases. The multifunctional A disintegrin and metalloproteinases (ADAMs) displaying the ability to cleave membrane-bound mediators or cytokines appear to be key mediators in various inflammatory processes. In the present study, we investigated ADAM-8 expression and production in a mouse model ...

The highly variable solar extreme ultraviolet (EUV) radiation is the major energy input to the Earth’s upper atmosphere, strongly impacting the geospace environment, affecting satellite operations, communications, and navigation. The Extreme ultraviolet Variability Experiment (EVE) onboard the NASA Solar Dynamics Observatory (SDO) will measure the solar EUV irradiance from 0.1 to 105 nm with un...