نتایج جستجو برای: esat 6 protein
تعداد نتایج: 2065964 فیلتر نتایج به سال:
سل یکی از معضلات بهداشتی و پزشکی جامعه بشری است، که از سالیان دور تا کنون باعث خسارات جانی و مالی فراوانی برای نسل بشر شده است.و علی رغم تمام تلاشهای صورت گرفته برای مقابله با این بیماری هنوز ان را به عنوان یکی از مهمترین علل مرگ و میر در دنیا می دانند که سالیانه 2 میلیون نفر را در دنیا به کام مرگ می فرستد. یکی از مهمترین پروتئینهای ایمنی زا در مایکوباکتریوم توبرکلوزیسesat-6است،که یک پلی پپتید...
Accurate diagnosis of tuberculosis (TB) infection is critical for the treatment, prevention, and control of TB. Conventional diagnostic tests based on purified protein derivative (PPD) do not achieve the required diagnostic sensitivity. Therefore, in this study, we have evaluated the immunogenic properties of Rv1168c, a member of the PPE family, in comparison with PPD, which is routinely used i...
Although IFN-γ release assays (IGRAs) provide increased specificity over tuberculin skin tests, the early and sensitive detection of reactivation of latently infected Mycobacterium tuberculosis is required to control tuberculosis (TB). Recently, a multicolor flow cytometry has been developed to study CD4(+) T cell cytokine responses (IFN-γ/IL-2/TNF-α) to purified protein derivatives (PPD) and M...
The currently used method for immunological detection of tuberculosis infection, the tuberculin skin test, has low specificity. Antigens specific for Mycobacterium tuberculosis to replace purified protein derivative are therefore urgently needed. We have performed a rigorous assessment of the diagnostic potential of four recently identified antigens (Rv2653, Rv2654, Rv3873, and Rv3878) from gen...
The Delayed type hypersensitivity skin test (DTH) and interferon-gamma assay are used for the diagnosis of bovine tuberculosis (TBB). The specificity of these diagnoses, however, is compromised because both are based on the response against purified protein derivative of Mycobacterium bovis (PPD-B). In this study, we assessed the potential of two cocktails containing M. bovis recombinant protei...
Bovine NK cells have recently been characterized and the present study describes the interaction between NK cells, antigen-presenting cells, and secreted mycobacterial proteins. Gamma interferon (IFN-gamma) production by NK cells was seen in approximately 30% of noninfected calves in response to the Mycobacterium tuberculosis complex-specific protein ESAT-6, MPP14 from Mycobacterium avium subsp...
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