Epithelial-mesenchymal transition (EMT) has been suggested to contribute to tumor progression and acquisition of therapeutic resistance. To assess the clinical significance of EMT-associated proteins, we evaluated the expression of Snail and Slug, the key regulators of EMT, in the primary ovarian cancer samples (n = 103) by immunohistochemistry. Snail was differentially expressed according to t...

Clear cell carcinoma (CCC) represents 2-10% of all epithelial ovarian cancers. 24-50% of the patients are known to have associated pelvic endometriosis. Women typically present between the ages of 40 and 70 with the peak incidence at age 52. CCC is rarely described in young females with youngest reported age being 23 years [1]. Risk factors for ovarian cancers include family history, age and nu...

The author reports two cases of adenosquamous carcinoma arising from endometriosis of ovaries. The tumor patients were 38-year-old and 53-year-old women. Both patients underwent hysterectomy and bilateral salpingo-oophorectomy for ovarian carcinomas. Grossly, both ovarian tumors were located in the left ovaries, and were cystic tumors with mural tumors. Histologically, the cystic areas consiste...

Cancer diagnosis and classification have traditionally been based on the assessment of morphology by microscopy. However, the histological classification system is challenging and demand for genetic information is increasing in the era of targeted and personalized molecular therapy. Recently accumulated comprehensive genomic data could be used to provide a molecular cancer classification alongs...

Endometrial carcinoma with a germ cell tumor component is a rare event. Here we report a uterine neoplasm with a unique combination of endometrioid adenocarcinoma and mixed germ cell malignant elements. A 28-year-old woman with abnormal vaginal bleeding, an abdominal mass, and elevated alfa-fetoprotein and beta-human chorionic gonadotropin (β-hCG) levels had a history of biopsy of an omental ma...

Uterine serous carcinoma (USC), while only comprising 10-120% of all endometrial cases, accounts for nearly half the deaths caused by this disease. Its aggressive nature is highlighted by the high risk of recurrence seen even in patients with disease limited to the uterus. The biology of these tumors is underpinned by genetic and molecular features, which are clearly distinct from the endometri...

Direct analysis of laser capture microdissected malignant and normal endometrial epithelium using matrix-assisted laser desorption/ionization (MALDI) time-of-flight mass spectrometry (MS) was able to detect a number of proteins that are overexpressed in malignant epithelial cells. A total of 16 physiologic and malignant endometrial samples were laser capture microdissected, including four proli...

Ovarian cancer is the leading cause of death from gynaecological malignancy in developed countries. Synchronous endometrioid endometrial and ovarian cancer in patients appears with different clinical characteristics compared to patients with isolated endometrial cancer. A 34-year-old woman with lower abdominal pain of 1 year duration presented at the emergency department. On gynaecological exam...

Endometrioid adenocarcinoma is the most common form (nearly 80%) of endometrial carcinoma. These tumors are referred to as ‘endometrioid’ because they resemble proliferative phase of the endometrium. It is common in postmenopausal women ([50 years) and presents as abnormal vaginal bleeding [1]. About 1–8% of these carcinomas occur in women less than 40 years. Small numbers of cases have been re...

Background. Patients with epithelial ovarian cancer have a high risk of (non-)melanoma skin cancer. The association between histological variants of primary ovarian cancer and skin cancer is poorly documented. Objectives. To further evaluate the risk of skin cancer based on the histology of the epithelial ovarian cancer. Methods. A cross-sectional study within a large population-based dataset. ...