Chiral α-branched allylic amines are important building blocks for organic synthesis, and several catalytic asymmetric methods have been developed for their synthesis. For example, enantioselective metal-catalyzed amination of allylic electrophiles 1 , 2 , 3 ] and rearrangement of allylic imidates have proven to be highly effective. An alternative approach to chiral allylic amines that can be a...

Diffuse interstitial pulmonary fibrosis in rheumatoid arthritis has received considerable attention since it was first described 20 years ago (Ellman and Ball, 1948). It appears that few authorities now doubt that the association is valid, despite the absence of statistical evidence from controlled investigations (Aronoff, Bywaters, and Fearnley, 1955; Talbott and Calkins, 1964; Stack and Grant...

AIM To investigate the potential tissue-protective effects of antioxidants selenomethionine and D-pantethine applied together with doxorubicin (Dx) on NK/Ly lymphoma-bearing mice. The impact of this chemotherapy scheme on animal survival, blood cell profile, hepatotoxicity, glutathione level, and activity of glutathione-converting enzymes in the liver was compared with the action of Dx applied ...

INTRODUCTION AND OBJECTIVE Acetylcholinesterase (AChE) and cholinergic receptors play an important role in the immune system, including lymphocyte-induced angiogenesis. However, their exact role is not fully understood. The presented work tests the influence of isopropyl methylphosphonofluoridate (IMPF), an irreversible inhibitor of AChE, on selected immune parameters associated with angiogenes...

Objective To investigate the association between the magnetic resonance imaging (MRI) findings of adhesive capsulitis and shoulder muscle fat percentages using a multi-echo Dixon method. Materials and Methods Twenty-four patients with clinical diagnoses of adhesive capsulitis and either intact rotator cuffs or Ellman grade 1 partial tears as indicated by MRI scans were included. Two radiologi...

Clinical reports suggest a positive association between fat consumption and the incidence of hyperactivity, impulsivity and cognitive abnormalities. To investigate possible mechanisms underlying these disturbances under short-term conditions, we examined in Sprague-Dawley rats the influence of 7-day consumption of a high-fat diet (HFD) compared to chow on anxiety, novelty-seeking and explorator...

BACKGROUND Long head biceps (LHB) degeneration, in combination with rotator cuff tears, can be a source of chronic shoulder pain. LHB tenotomy reduces pain and improves joint function although the pathophysiological context is not well understood. Tendon integrity depends on the extracellular matrix (ECM), which is regulated by matrix metalloproteinases (MMP). It is unclear which of these enzym...

6 Islam A. A new bone marrow biopsy needle with core securing device. J Clin Pathol 1982;35:359-64. 7 Ellman L. Bone marrow biopsy in the evaluation of lymphoma, carcinoma and granulomatous disorders. Am J Med 1976;60:1-6. 8 Burke JS. The value of the bone marrow biopsy in the diagnosis of hairy cell leukaemia. Am J Clin Pathol 1978;70:876-84. 9 Islam A, Catovsky D, Goldman JM, Galton DAG. Valu...

It has been known for many years that there is a 24-hour cycle of intraocular pressure (IOP) in normal subjects and in patients with glaucoma (Boyd and McLeod, i964; Drance, i963; DukeElder, I952; Ericson, 1958; Katavisto, I964; Langley and Swanljung, 195I; Maslenikow, 1904; Thiel, 1925). On the basis of infrequent measurements (generally two to four times per day), the highest pressures have b...