Extracellular matrix (ECM) proteins are biosynthesized in the rough endoplasmic reticulum (rER) and transported via the Golgi apparatus to the extracellular space. The coat protein complex II (COPII) transport vesicles are approximately 60-90 nm in diameter. However, several ECM molecules are much larger, up to several hundreds of nanometers. Therefore, special COPII vesicles are required to co...

The hitherto inconsistency in clinical performance for engineered skin drives the current development of novel cell-scaffolding materials; one challenge is to only extract essential characteristics from the complex native ECM (extracellular matrix) and incorporate them into a scaffold with minimal complexity to support normal cell functions. This study involved small-molecule-based bioactive hy...

This paper reports record-setting performance for the ellipticcurve method of integer factorization: for example, 604.99 curves/second for ECM stage 1 with B1 = 8192 for 280-bit integers on a single PC. The state-of-the-art GMP-ECM software handles 171.42 curves/second for ECM stage 1 with B1 = 8192 for 280-bit integers using all four cores of a 2.4GHz Core 2 Quad Q6600. The extra speed takes a...

18.1 Context of the ECM ...................................................... 461 18.1.1 ECM – What’s in a Name? ............................................. 462 18.1.2 Old and New ECMs ........................................................ 462 18.1.3 Biophysical Considerations ............................................. 462 18.1.4 Jelly Bombs ................................................

Accumulation of monocyte-derived foam cells in focal areas of the atherosclerotic (A.S.-) lesion is one of the key events in early atherogenesis. Using a flow model for the damaged vessel wall, we examined the ability of ECM-bound platelets to induce monocyte tethering and adhesion. Whereas ECM-proteins alone induced monocyte adhesion only at low shear stresses (< 100 mPa), ECM-bound platelets ...

Multicellular spheroids of a human glioma cell line (U-118 MG) and a human thyroid cancer cell line ( HTh -7) were analyzed for the presence of extracellular matrix (ECM) using light microscopy, transmission electron microscopy, and indirect immunofluorescence staining for fibronectin, laminin, and collagen. These studies were supplemented by analyses of glycosaminoglycans using autoradiography...

Cells exhibit a biphasic migration-velocity response to increasing adhesion strength, with fast migration occurring at intermediate extracellular matrix (ECM) concentration and slow migration occurring at low and high ECM concentration. A simple mechanical model has been proposed to explain this observation, in which too little adhesion does not provide sufficient traction whereas too much adhe...

the impact of price changes (at a level of market) on the other market levels (transfer of prices) will affect welfare of producers, marketing agents as well as consumers. in this study, asymmetric tea market is investigated through an application of johansen co-integration analysis and error correction model (ecm model) to time series of 1976-2009. co integration method used in the import mark...

We introduced the spectrum-adapted expectation-conditional maximization (ECM) algorithm to improve efficiency of peak fitting spectral data by various models. The ECM can perform using Pseudo–Voigt mixture model and Doniach–Šunjić–Gauss which are generally used for in X-ray photoelectron spectroscopy. Analyses synthetic experimental showed that proposed method quickly completed calculation esti...

The aim of this work is to understand more closely where the border lies between relational and Not Only Structured Query Language (NoSQL) platform as concerns Enterprise Content Management (ECM) area. Another objective (closely related to the first one) is to specify the conceptual architecture of the distributed ECM system. The authors specify the model of the prototype ECM system and compare...