background: white button mushroom (agaricus bisporus) is a sensitive agricultural crop whose antioxidant properties are decreased during postharvest storage. in this study, the effect of citric acid dipping treatment on bioactive components and antioxidant properties of sliced button mushroom (agaricus bisporus) was investigated. methods: fresh mushrooms soaked in chilled citric acid solution a...

background cancer is one of the leading causes of human death. the discovery of new generations of low-cost anticancer drugs with high efficacy and low toxicity is necessary, and is only possible by screening medicinal plants with prior knowledge. objectives in this study, the bioactivities of three medicinal plants from india, including alstonia scholaris, alstonia venenata, and moringa oleife...

BACKGROUND Advanced glycation end products (AGEs) and free radicals are inflammatory mediators and are implicated in many diseases such as diabetes, cancer, rheumatoid arthritis etc. Multi targeted poly herbal drug systems like Nawarathne Kalka (NK) are able to quench the overall effect of these mediators as they contain good combinations of phytochemicals that have least side effects in contra...

this study was carried out to evaluate the antifungal efficacy of garlic essential oil (allium sativum l.) and two fungicides including metalaxyl- mancozeb and mancozeb against phytophthora melonis, p. drechsleri and p. capsici the causal agent of damping- off on pepper, melon and cucumber, in vitro and greenhouse conditions. fungal radial growth for each concentration of garlic oil on phytopht...

Alfalfa plants (Medicago sativa cv. Europe) inoculated with Sinorhizobium meliloti 2011 (formerly Rhizobium meliloti, de Lajudie et al., 1994) were cultivated for 14 days under standardized growth conditions in mineral medium with addition of the heavy metal cadmium or the polycyclic aromatic hydrocarbon fluoranthene. These xenobiotics significantly reduced the numbers of root nodules before an...

Abstract To investigate the in vitro anthelmintic efficacy of dividivi (Caesalpinia coriaria), a traditional medicinal plant used Central America and northern part South America, extracts from foliage this were subjected to egg hatching test (EHT) larval exsheathment inhibition (LEIT), against Haemonchus contortus. Four different evaluated: acetone-water (AW), methanol-water (MW), acetone-water...

Titanium dioxide is a type of nanoparticle that composed one titanium atom and two oxygen atoms. One its physicochemical activities photolysis, which produces different reactive species (ROS). Atya lanipes shrimp affect detrital processing illustrate the potential importance diversity nutrient availability to rest food web. It essential in removing sediments, have an important role preventing e...

INTRODUCTION We evaluated the in vitro antimalarial activity of tigecycline as an alternative drug for the treatment of severe malaria. METHODS A chloroquine-sensitive Plasmodium falciparum reference strain, a chloroquine-resistant reference strain, and three clinical isolates were tested for in vitro susceptibility to tigecycline. A histidine-rich protein in vitro assay was used to evaluate ...

A series of acyclic selenopurine nucleosides 3a-f and 4a-g were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-dia...

A quinazolinedione-derived screening hit 2 was discovered with cellular antiviral activity against respiratory syncytial virus (CPE EC50 = 2.1 μM), moderate efficacy in reducing viral progeny (4.2 log at 10 μM), and marginal cytotoxic liability (selectivity index, SI ∼ 24). Scaffold optimization delivered analogs with improved potency and selectivity profiles. Most notable were compounds 15 and...