Dysplastic nevi are described as being on a continuum between common acquired nevi and melanoma because they are morphologically and biologically intermediate between these 2 entities. Since initially being reported as histologic lesions observed in melanoma-prone families, there has been considerable debate about the definition of dysplastic nevi, the histologic and clinical criteria used to d...

Multicystic dysplastic kidney (MCDK) is a renal abnormality that contains multiple cysts of various shapes and sizes in the kidney. Unilateral MCDK is very common in children and usually is associated with other contralateral anomalies. There are a few different etiology theories that are being evaluated, but the origination is still uncertain. Although there is no cure for MCDK, there are a fe...

introduction: the impact of chromium exposure was studied on liver, kidney, testis, spleen, cerebrum and cerebellum of male wistar rats (80-100 g body weight). material & method: it was observed that treatments of rats with chromium (i.p. at a dose of 0.8 mg / 100 g body weight per day) for a period of 28 days caused significant increase in chromium content while declining the body weight along...

Myoinositol is an isomer of glucose that has chemopreventive activity in animal models of cancer. In a recent phase I clinical trial, myoinositol administration correlated with a statistically significant regression of preexisting bronchial dysplastic lesions in heavy smokers. To shed light on the potential mechanisms involved, activation of Akt and extracellular signal-regulated kinase (ERK), ...

Hip dysplasia is a major cause of osteoarthrosis in adults. Early aggressive osteotomy has the potential of preventing the development of arthritis, but carries with it significant risks. The problem is further complicated because the surgeon has no means of quantifying the dysplastic deformity or of predicting what a particular combination of osteotomies would do to correct the deformity. This...