Malingering is the intentional production of false or grossly exaggerated symptoms in order to obtain an advantage. Although it has been estimated that over 800,000 claims for personal injury in Road Traffic Accidents (RTA) were filed in the UK in 2012, no approximation exists for how many involved malingering. This study attempts to understand what influences a psychiatrist to conclude that a ...

As an essential step in the lytic cascade, the Rta homologues of gammaherpesviruses all activate their own expression. Consistent with this biologic function, the Epstein-Barr virus (EBV) Rta protein powerfully stimulates the promoter of its own gene, Rp, in EBV-positive B cells in transient-transfection reporter-based assays. We analyzed the activity of RpCAT in response to Rta by deletional a...

Bardoxolone methyl, a synthetic triterpenoid, improves the estimated glomerular filtration rate (GFR) in patients with chronic kidney disease and type 2 diabetes. Since the contractile activity of mesangial cells may influence glomerular filtration, we evaluated the effect of the synthetic triterpenoid RTA 405, with structural similarity to bardoxolone methyl, on GFR in rats and on mesangial ce...

Schedulability analysis of xed priority preemptive scheduled systems can be performed by calculating the worst-case response-time of the involved processes. The system is deemed schedulable if the calculated response-time for each process is less than the corresponding deadline. It is desirable that the employed Response-Time Analysis (RTA) can be eeciently performed. This is particularly impor...

The longitudinal ~LA! Brillouin back-scattering spectra along the @001# phonon direction have been measured as a function of temperature for RbTiOAsO4 ~RTA! and KTiOPO4 ~KTP! single crystals. As temperature increases, the acoustic-phonon frequencies of RTA and KTP show a clear softening ~which reaches a turning point at Tc;800 °C for RTA!. We conclude that the transitions in RTA and KTP are eit...

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcriptional factor that regulates many antioxidants, and we have recently succeeded in obtaining a novel Nrf2 activator, RS9, from microbial transformation. RS9 is categorized as a triterpenoid, and well-known triterpenoids such as RTA 402 (bardoxolone methyl) and RTA 408 have been tested in clinical trials. RTA 408 lotion is currently...

We present a method for providing response-time guarantees for multimedia traffic in Asynchronous Transfer Mode (ATM) networks. The method extends our ResponseTime Analysis (RTA) for ATM networks to better capture the behaviour of MPEG-type multimedia traffic. RTA is intended for admission control of hard real-time traffic, i.e., it determines if a new connection can be admitted without violati...

Ricin A chain (RTA) undergoes retrograde trafficking and is postulated to use components of the endoplasmic reticulum (ER) associated degradation (ERAD) pathway to enter the cytosol to depurinate ribosomes. However, it is not known how RTA evades degradation by the proteasome after entry into the cytosol. We observed two distinct trafficking patterns among the precursor forms of wild type RTA a...

The lytic switch protein RTA of Kaposi's sarcoma-associated herpesvirus (KSHV) can be targeted to DNA by either direct sequence-specific recognition or via protein-protein interactions with host transcription factors. We have searched for sequences capable of direct RTA binding by screening synthetic oligonucleotide pools and KSHV genomic libraries for RTA-interacting elements, using repeated c...

PURPOSE To assess the reproducibility of retinal thickness measurements in normal subjects and to compare foveal thickness using optical coherence tomography (OCT) and the scanning retinal thickness analyzer (RTA). METHODS Two examiners performed foveal thickness measurements in 24 eyes of 12 healthy subjects using both OCT and the scanning RTA. Intraclass correlation coefficients (ICC) (intr...