The morbidity and mortality associated with diabetic complications impose a huge socioeconomic burden worldwide. Therefore, the ultimate goal of managing diabetes mellitus (DM) is to lower the risk of macrovascular complications and highly morbid microvascular complications such as diabetic nephropathy (DN) and diabetic retinopathy (DR). Potential benefits of incretin-based therapies such as gl...

Vascular complications are the leading causes of morbidity and mortality in diabetic patients. The contribution of platelets to thromboembolic complications is well documented, but their involvement in the initiation of the atherosclerotic process is of rising interest. Thus, the aim of the present study was to evaluate basal arachidonic acid metabolism in relation to the redox status of platel...

The unique demands of exercise and competition can predispose diabetic athletes to harmful complications. A basic understanding of glucose metabolism during exercise, nutritional adequacy, blood glucose control, medications, and management of on-field complications is important for medical personnel who care for diabetic athletes on a daily basis. Diabetic athletes are best managed by "individu...

The management of diabetic foot disease may seem poorly defined by comparison with complications such as nephropathy, hyperlipidaemia and retinopathy, for which clear guidelines exist. A multidisciplinary team, approach, particularly in specific diabetic foot clinics, is very successful in avoiding and treating foot complications, This strategy has been shown to reduce both the incidence of maj...

It’s not always the case that it’s easy to forgive and forget, particularly when it comes to past memories. The concept of the legacy effect or hyperglycemic memory describes the deferred consequence of antecedent glycemic status on the development of diabetic complications. Anyone researching chronic hyperglycemia appreciates that glucose is still considered the major risk factor implicated in...

BACKGROUND Small dense low density lipoprotein (sdLDL) has recently emerged as an important risk factor of coronary heart disease. METHODS The mean LDL particle size was measured in 203 patients with type 2 diabetes mellitus (T2DM) and 212 matched subjects without diabetes using polyacrylamide tube gel electrophoresis. Major vascular complications were defined as stroke, angiographically-docu...

Diabetic patients with and without complications show a difference in serum uric acid pattern in relation to duration of disease along with glycemic status, lipid derangements and complications associated with the disease. HbA1c studies were taken to know the blood sugar levels for the past 3 months to assess the glycemic control. Study of lipid profile is also taken to assess the micro vascula...