objective: autism results from developmental factors that affect many or all functional brain systems. brain is one of tissues which are crucially in need of adenosine triphosphate (atp). autism is noticeably affected by mitochondrial dysfunction which impairs energy metabolism. considering mutations within atpase 6, atpase 8 and trnalys genes, associated with different neural diseases, and the...

Advancements in DNA sequencing technologies with decreasing costs have sparked the generation of larger gene expression datasets generated at an accelerating rate. The study aimed to visualize spatiotemporal profiles tomato (Solanum lycopersicum L.) genes involved L-proline biosynthesis and show their potential functions. Increasing accumulation, through upregulation downregulation responsible ...

Three unrelated patients with similar microdeletions of chromosome 14q32.11 shared phenotypes including language and developmental delay, four overlapping genes -CALM1, TTC7B, PSMC1, RPS6KA5 have been presented. All are expressed in the brain haploinsufficiency scores, which reflect low tolerance to loss function variation. An insight on region, may influence resulting phenotype has provided. G...

While regulation of the activity of developmental control genes at the transcriptional level as well as by specific miRNA-based degradation are intensively studied, little is known whether general cellular mechanisms controlling mRNA decay may contribute to differential stability of mRNAs of developmental control genes. Here, we investigate whether a mutation in the deadenylation dependent mRNA...