OBJECTIVE To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN We measured concentrations of leuprolide, LH, and follicle-stimulating hormone (FSH) at multiple time points before and after the first dose of de...

This paper considers the Dynamic Multi-Period Vehicle Routing Problem which deals with the distribution of orders from a depot to a set of customers over a multi-period time horizon. Customer orders and their feasible service periods are dynamically revealed over time. The objectives are to minimize total travel costs and customer waiting, and to balance the daily workload over the planning hor...

This paper considers the Dynamic Multi-Period Vehicle Routing Problem which deals with the distribution of orders from a depot to a set of customers over a multi-period time horizon. Customer orders and their feasible service periods are dynamically revealed over time. The objectives are to minimize total travel costs and customer waiting, and to balance the daily workload over the planning hor...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

AIMS AND METHOD To establish if participants with schizophrenia receiving depot antipsychotics had less insight than similar participants receiving oral atypical antipsychotics.We assessed the difference between these two groups. RESULTS Participants on oral antipsychotics had greater insight than those on depot antipsychotics (ITAQ, P=0.01). In the multiple regression analysis, only receiving ...

Abstract This study aims to design a route optimization model support commodity distribution in the Moluccas archipelago zone. The is designed using an integer programming approach for multi-depot multi-cluster with aim of minimizing distance. In this case, several points on island must be serviced. Each service point will only choose one port serve. Sea transportation routes are formed from se...