Huntington's Disease (HD) is a progressive neurodegenerative disorder that causes motor, cognitive, and psychiatric symptoms. In these experiments, we tested if operant training at an early age affected adult cognitive deficits in the zQ175 KI Het (zQ175) mouse model of HD. In Experiment 1 we trained zQ175 mice in a fixed-ratio/progressive ratio (FR/PR) task to assay learning and motivational d...

objective(s):previous research demonstrated that diabetes is one of the leading causes of learning and memory deficits. naringin, a bioflavonoid isolated from grapefruits and oranges, has potent protective effects on streptozotocin (stz)-induced diabetic rats. recently, the effects of naringin on learning and memory performances were monitored in many animal models of cognitive impairment. howev...

objective: interventions for people suffering from borderline personality disorder (bpd), such as dialectical behavior therapy, often include a problem-solving component. however, there is an absence of published studies examining the problem-solving abilities of this client group in iran. the study compared inpatients and outpatients with bpd and a control group on problem-solving capabilities...

the main purpose of this paper is analyses the short and long run relationship between budget deficit and trade deficit in some mena countries. the data cover the period from 1971-2000 (and for i.r. iran 1 959-2003).the relationship between these variables will be analyses in short and long run by using johansen cointegration tests, ecm, and granger causality test. the empirical evidence provid...

background: diabetes mellitus is associated with cognitive deficits in humans and animals. these deficits are paralleled by neurophysiological and structural changes in brain. in diabetic animals, impairments of spatial learning, memory, and cognition occur in association with distinct changes in hippocampus, a key brain area for many forms of learning and memory and are particularly sensitive ...

introduction: a large body of evidence points to oxidative stress as prime candidate mediating the behavioral impairments and memory deficits in alzheimer's disease (ad). it has been demonstrated that hyperoxia preconditioning activates complex endogenous neuroprotective mechanisms including an increase in capacity of antioxidant defence mechanisms. the aim of this study was to investigate...

As people age, they accumulate deficits. The more deficits they accumulate, the greater their vulnerability, which can be expressed as the probability to accumulate even more deficits, or to die. The probability of death is known to be exponentially related to the number of deficits. Using data from elderly (aged 65 + years) participants in the Canadian Study of Health and Aging (n = 9008), we ...

nfl S it, HERE HAS BEEN considerable concern about the size of the federal deficit and the rather modest success of the Gramm-RudmanHollings Act to reduce it. The traditional, that is, Keynesian, view of deficit spending in macroeconomics was that it could smooth out fluctuations in economic activity due to gaps between saving and investment that were primarily the result of exogenous shifts in...