نتایج جستجو برای: deficient diet
تعداد نتایج: 245368 فیلتر نتایج به سال:
Hyperhomocysteinemia is a risk factor for stroke, myocardial infarction, and venous thrombosis. Moderate hyperhomocysteinemia is associated with impaired endothelial function, but the mechanisms responsible for endothelial dysfunction in hyperhomocysteinemia are poorly understood. We have used genetic and dietary approaches to produce hyperhomocysteinemia in mice. Heterozygous cystathionine bet...
Forty entire male pigs from a commercial crossbreed (Duroc × Large White × Landrace) were used to investigate the individual or combined effects of betaine and Arg supplementation in Lys-deficient diets on growth performance, carcass traits, and pork quality. Pigs with 59.9 ± 1.65 kg BW were randomly assigned to 1 of 5 dietary treatments ( = 8). The 5 dietary treatments were normal Lys and CP d...
OBJECTIVE Previous studies suggested that microRNA-21 may be upregulated in the liver in non-alcoholic steatohepatitis (NASH), but its role in the development of this disease remains unknown. This study aimed to determine the role of microRNA-21 in NASH. DESIGN We inhibited or suppressed microRNA-21 in different mouse models of NASH: (a) low-density lipoprotein receptor-deficient (Ldlr-/-) mi...
UNLABELLED Pyruvate dehydrogenase complex (PDC) deficiency is a major inborn error of oxidative metabolism of pyruvate in the mitochondria causing congenital lactic acidosis and primarily structural and functional abnormalities of the central nervous system. To provide an alternate source of acetyl-CoA derived from ketone bodies to the developing brain, a formula high in fat content is widely e...
zinc (zn) as a nutritional factor affects the health of the oral tissues. this study was done for the evaluation of the effects of zinc deficiency on the oral tissues of rats. the study was carried out on 14 male wistar rats, cessation of lactation on the 24th day after birth. the rats were randomly divided into two groups. zinc deficient (zd) diet was used for one group and another group was f...
Two experiments were conducted to test the effect of casein and soy protein isolate (SPI) on the nutritional status of vitamin B(6) in rats. Adult Long-Evans rats were fed with a casein or SPI diet at a 40% protein level with (control) or without (B(6)-deficient) 7 mg of pyridoxine/kg diet. Vitamin-B(6)-deficient rats were depleted of B(6) with (experiment 1) or without (experiment 2) deoxypyri...
BACKGROUND Oxaliplatin is an anticancer drug used for the treatment of advanced colorectal cancer, but it can also cause painful peripheral neuropathies. The pathophysiology of these neuropathies has not been yet fully elucidated, but may involve spinal N-methyl-D-aspartate (NMDA) receptors, particularly the NR2B subunit. As polyamines are positive modulators of NMDA-NR2B receptors and mainly o...
Liver NAD and NADH each decreased by 25 to 40% in animals fed a nicotinamide-deficient diet for 4 weeks. In contrast, the nicotinamide-deficient diet had a negligible effect on the amount of liver NADP and NADPH, suggesting a closer regulation by the body of the levels of the latter two compounds. Adrenal steroids prevented the depletion of NAD and NADH which otherwise occurred in rats fed the ...
Liver fatty acid metabolism of male rats fed on a vitamin A-deficient diet for 3 months from 21 d of age was evaluated. Vitamin A restriction produced subclinical plasma and negligible liver retinol concentrations, compared with the control group receiving the same diet with 4000 IU vitamin A (8 mg retinol as retinyl palmitate)/kg diet. Vitamin A deficiency induced a hypolipidaemic effect by de...
Young male Sprague-Dawley rats were fed 0, 1, 10, or 100 ppm of polybrominated biphenyls (PBB) in iodine-deficient, iodine-adequate (0.2 ppm), or iodine-excess (1000 ppm) diets. Six rats in each of the 12 groups were killed at 30 days and the remaining six in each group at 60 days. Growth rates were similar in all rats fed diets containing 0, 1, or 10 ppm PBB but were slower from 30 to 60 days ...
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