Blood samples obtained from the coronary sinus in man contain venous blood draining from left ventricular myocardium. It is believed by many investigators that coronary sinus blood in man is composed almost entirely of left ventricular efflux. That this is true in the canine heart is firmly established (Rayford et al., 1959). This principle has been widely accepted in the many studies which hav...

The effects of sodium nitroprusside alone and in combination with phenylephrine were studied at the time of cardiac catheterisation in 10 patients with normal left ventricular function. Nitroprusside was infused to reduce mean arterial pressure in 5 patients with the heart rate free (group 1) and in 5 with the heart rate fixed by atrial pacing (group 2). In group 1 nitroprusside increased heart...

A 45-year-old male with no significant medical history or risk factors for coronary disease presented with a 1-year history of intermittent, exertional chest pain radiating to the neck. Physical examination was unremarkable. An EKG was normal. A chest X-ray, however, revealed a 4-cm round focus with peripheral calcification overlying the left side of the heart. A computed tomography (CT) of the...

The effects of metabolic coronary vasodilation on transcapillary exchange in the heart were examined in anesthetized dogs by use of the multiple indicator dilution technique. Animals were studied under basal conditions and during coronary sinus pacing. To obviate adrenal medullary stimulation, catheters were placed in coronary artery and coronary sinus in a closed chest preparation. Plasma cate...

A 60 year old man with a history of frequent episodes of chest pain and dizziness was referred for evaluation of coronary artery disease. He had no significant coronary artery stenosis at baseline coronary angiography. A carotid sinus massage was performed for evaluation of carotid sinus hypersensitivity in the patient. Both heart rate and blood pressure decreased a little, and returned to base...

• The high incidence of coronary artery disease in man has prompted extensive research efforts in the direction of improving blood flow to the heart muscle. Attempts to achieve this goal have taken many forms and may be summarized as follows: (1) scarifying procedures designed to encourage the growth of new vascular channels into the heart from extracardiac sources; (2) retrograde perfusion of ...

DESCRIPTION A 71-year-old man was admitted with a 2-day history of intermittent palpitations. His initial ECG demonstrated a supraventricular tachycardia with a heart rate of 170 bpm. Following treatment with verapamil he reverted to sinus rhythm. As part of his initial investigations he had a two dimensional transthoracic echocardiogram. The parasternal long axis view demonstrated a well-circu...

It has been known that exercise causes an increase in the coronary blood flow in animals. The present work has been carried out to study the effect of exercise on coronary blood flow and myo-cardial oxygen consumption of the human heart in vivo. The results indicate that the heart responds to the increased load of exercise with a rise in coronary blood flow. Since the arteriovenous coronary oxy...

BACKGROUND Access to data on the coronary flow in the coronary sinus (CS) can aid in the diagnosis of coronary artery disease (CAD). We tested the hypothesis that assessing the CS flow by transthoracic Doppler echocardiography (TTE) at rest can detect coronary artery stenosis in non-hypertensive patients. METHODS The antegrade phase of coronary flow in the CS was analyzed and compared in 140 ...

Background: Several large epidemiological outcome studies did not demonstrate a benefit of combined estrogen-progestin replacement treatment (HRT) on cardiovascular events in elderly postmenopausal women. Whether progestin antagonism is responsible for these negative results or the natural estrogen 17ß-estradial (E2) itself is not effective in the coronary circulation is unknown. Aim: To assess...