Abstract Tumor associated microglia and macrophages (TAMs) represent a main cell type of brain malignancies demonstrate complex interactions with cancerous cells the tumor microenvironment. These have important implications for progression treatment malignant central nervous system (CNS) tumors. In non-oncological context, it has been shown that endogenous can be replaced by peripheral hematopo...

The incidence rate of central nervous system tumors in the USA is 14.8/100,000 people per year.1 Within these, the malignant CNS tumors are accountable for at least 12,760 deaths for the year 2005 (1). The CNS tumors incidence in the USA is associated with male gender, Caucasian race, metropolitan area residents, and the elderly population (2). CNS tumor incidence in the USA has been studied an...

Immunotherapy is an efficient approach to clinical oncology. However, the immune privilege of central nervous system (CNS) limits application immunotherapeutic strategies for brain cancers, especially glioblastoma (GBM). Tumor resistance checkpoint inhibitors a further challenge in immunotherapies. To overcome immunological tolerance tumors, novel multifunctional nanoparticle (NP) highly synerg...

BACKGROUND Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are effective against tumor EGFR-mutated non-small cell lung cancer (NSCLC). Patients with the tumor EGFR-activating mutation (EGFRmu) had superior survival, compared to patients with EGFR wild-type tumors (EGFRwt). Many patients with the EGFRmu have had disease progression with EGFR-TKI treatment because of cent...

background: malignant neoplasms remain the second leading cause of death in children after accidents. the aim of this study was to assess the epidemiology of childhood cancer in children admitted to dr sheikh hospital, iran. materials and methods: this descriptive cross- sectional study had been done in dr sheikh hospital in mashhad university of medical science on 1764 children younger than 14...

Abstract Despite advances in solid tumor biology and oncology, pediatric adult primary brain cancer metastasis to the harbor dismal prognosis poor outcomes. One avenue overcome these clinical challenges is through developing robust immunotherapy better target tumor. Our group has previously shown that adoptive cellular therapy (ACT) provides therapeutic benefit against central nervous system (C...

crush preparation cytology technique was used during the operative procedure for the diagnosis of 199 cns tumors. this technique is simple, easy to perform, rapid, and inexpensive. the cytomorphologic findings were excellent and helped achieve a rapid and correct diagnosis. this technique was used on the tiny, small specimens which were not suitable for frozen sectioning. the results were compa...

Background: Malignant neoplasms remain the second leading cause of death in children after accidents. The aim of this study was to assess the epidemiology of childhood cancer in children admitted to Dr sheikh hospital, Iran. Materials and Methods: This descriptive cross- sectional study had been done in Dr Sheikh Hospital in Mashhad University of medical science on 1764 children younger than 1...

The orphan G protein-coupled receptor (GPCR) GPR124/tumor endothelial marker 5 is highly expressed in central nervous system (CNS) endothelium. Here, we show that complete null or endothelial-specific GPR124 deletion resulted in embryonic lethality from CNS-specific angiogenesis arrest in forebrain and neural tube. Conversely, GPR124 overexpression throughout all adult vascular beds produced CN...

Nestin is an intermediate filament protein (IFP) expressed in undifferentiated cells during CNS development and in CNS tumors. Previous studies have arrived at different conclusions in terms of which types of CNS tumors express nestin. In this report we establish an immunohistochemical protocol using antigen retrieval, which significantly enhances staining with two polyclonal anti-nestin antise...