scleromyxedema is a rare, chronic, progressive, fibromucinous disorder of unknown etiology, characterized by lichenoid waxy papules and firm induration of skin of trunk, face, forearm and hands; fibroblast proliferation and mucin deposition in the upper dermis. cutaneous involvement is characteristic but there are several associated systemic manifestations: we observed a case of scleromyxedema ...

multiple sclerosis (ms) is a demyelinating disease of the central nervous system,with unknown etiology in which both genetic and environmental factors are thought to be involved. the hla system provides a set of genetic markers which lend themselves to systematic study. the disease also has variable clinical manifestations, ranging from a relapsing-remitting course to a chronic progressive dise...