PurposeChronic lung allograft dysfunction (CLAD) is the primary cause of long-term mortality after transplantation. Aspiration bile acids has been associated with CLAD and lipidomic dysregulation. This study evaluates role large airway bronchial wash (LABW) lipidomics diagnosis CLAD.MethodsLABW (n=611) samples were obtained from 305 transplant recipients at different timepoints. Concentrations ...

1. Lifelong monitoring of graft function, immunosuppressive levels, and screening for drug toxicity is required in all liver recipients. 2. Late hepatic allograft dysfunction is common and is caused by a variety of etiologies including rejection, infection, biliary/vascular abnormalities, recurrence of disease, and drug hepatotoxicity. 3. In all patients with late hepatic allograft dysfunction,...