Intracellular glucose and lipid metabolic homeostasis is vital for maintaining basic life activities of a cell or an organism. Glucose and lipid metabolic disorders are closely related with the occurrence and progression of diabetes, obesity, hepatic steatosis, cardiovascular disease, and cancer. Chlorogenic acid (CGA), one of the most abundant polyphenol compounds in the human diet, is a group...

Many real-world optimisation problems are dynamic. For such problems the goal is to track the progression of optimal solutions across the fluctuating fitness landscape rather than to find an exceptionally good solution for a static instance of the problem. Here we present a novel approach for creating robust solutions for non-stationary problems using the Cellular Genetic Algorithm (CGA). The C...

The two major proteins of the secretory vesicles of neuroendocrine cells, chromogranin A (CGA) and chromogranin B (CGB), have been shown to undergo pH- and Ca2+-dependent conformational changes and aggregation and have been suggested to play essential roles during secretory vesicle biogenesis in the trans-Golgi network. CGA has been shown to exist primarily in a tetrameric state at pH 5.5 and p...

Human chromogranin A (CgA) is a secretory protein that is used as a tissue marker for neuroendocrine tumors (NETs) (1,2). In patients with carcinoids and pheochromocytomas, CgA is a more stable marker than plasma levels of serotonin, catecholamines and their urinary metabolites (3). It may also be elevated due to several other causes; however, the use of proton pump inhibitors (PPIs) is the mos...

Chromogranin A (CgA) is gaining acceptance as a serum marker of neuroendocrine tumors. Its specificity in differentiating between neuroendocrine and nonneuroendocrine tumors, its sensitivity to detect small tumors, and its clinical value, compared with other neuroendocrine markers, have not clearly been defined, however. The objectives of this study were to evaluate the clinical usefulness of C...

Short-term power load forecasting is critical for ensuring system stability. A new algorithm that combines CNN, GRU, and an attention mechanism with the Sparrow to optimize variational mode decomposition (PSVMD–CGA) proposed address problem of effect random fluctuations on accuracy short-term forecasting. To avoid manual selection VMD parameters, adopted by decomposing data into multiple subseq...

OBJECTIVE Proton pump inhibitors (PPIs) are used primarily to treat gastroesophageal reflux disease. Proton pump inhibitor-induced achlorhydria increases circulating gastrin and chromogranin A (CGA). Chromogranin is a widely used biomarker for the diagnosis and follow-up for gut-based neuroendocrine tumors (NETs). Proton pump inhibitor-induced increases in CGA or gastrin may falsely suggest the...

The incidence of cancer increases with advanced age and the majority of cancer deaths are in patients aged ≥ 65. The geriatric population is a heterogeneous group and a patient's chronologic age does not always correlate with underlying physiologic status. Oncologists need to be able to obtain information on physiologic and functional capacity in older patients in order to provide safe and effe...

Chromogranins (Cgs) are acidic proteins that have been described in the large, dense core vesicles (LDCVs) of adrenal chromaffin cells and that have been shown to promote LDCV formation, even in nonsecretory cells. Catecholamines (CAs) are adsorbed by Cgs in vitro, and the absence of Cgs modifies the storage and exocytosis of CAs in chromaffin cells. In this study, we set out to assess the role...

OBJECTIVES Meniere's disease (MD) is an inner ear disorder characterized by episodic vertigo, ear fullness, and hearing loss; usually vertigo attacks cluster in specific period. We studied in MD patients the circulating levels of chromogranin A (CgA) and vasostatin-1 (VS-1), secreted by the neuroendocrine system and involved in the regulation of the endothelial barrier function. METHODS Serum...