conclusions the applied therapy adaptation before and after exercises was adequate to avoid hypoglycemia while using an ultra-long-acting insulin. objectives the aim of this experimental, cross-sectional study was to investigate exercise intensity-dependent, short-acting insulin reductions to avoid hypoglycemia, applying standardized exercises using insulin degludec (®tresiba/novo nordisk, denm...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Kira Allmeroth author on ‘ N1-acetylspermidine determinant hair follicle stem cell fate’, JCS. conducted research described this article while PhD student Martin Denzel's lab at Max Planck Insitute ...

Introduction: Metabolic reprogramming is a hallmark of cancer progression. However, there are few studies in mantle cell lymphoma (MCL). Protein arginine methyltransferase 5 (PRMT5), catalyzes monomethylation and symmetric demethylation residues on histone nonhistone proteins participates tumor This study aimed to investigate the mechanism PRMT5-induced lipid MCL. Method: Lymph node, bone marro...

With an ever-increasing demand for biopharmaceuticals, there is a growing need high-producing industrial cell lines. 13C metabolic flux analysis provides comprehensive perspective of host metabolism by rigorously quantifying fluxes within intracellular networks. The characterization production lines altered via engineering or media optimization can help to identify desirable phenotypes. Coupled...

The majority of marine microbes remain uncultured, which hinders the identification and mining CO 2 -fixing genes, pathways, chassis from oceans. Here, we investigated in seawater euphotic zone Yellow Sea China by detecting tracking their 13 C-bicarbonate ( C-HCO 3 - ) intake via single-cell Raman spectra (SCRS) analysis. target cells were then isolated Raman-activated Gravity-driven Encapsulat...

Acute myeloid leukemia (AML) is a heterogeneous disease with poor clinical outcomes. We have previously shown that constitutive activation of NADPH oxidase 2 (NOX2), resulting in over-production reactive oxygen species (ROS), occurs over 60% AML patients. also increased ROS production promotes glucose uptake and proliferation cells, mediated by changes carbohydrate metabolism. Given carbohydrat...

Bone is a dynamic organ that, once formed, undergoes constant remodeling process that includes bone resorption and synthesis. Osteoclasts osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed XBP1 plays vital role metabolism, includ...

iron is essential to erythrocyte oxygen transport and is a catalyst for oxidative metabolism in all cells. iron is absorbed by the duodenum and requires an acidic environment for optimal absorption. iron is found for 70% in erythrocytes, and 30% in storage, and a small amount in myoglobin and cytochromes. iron supplementation reduces anemia in breastfed infants and increases in significant dose...