objective(s): binary hybrids of chitosan-zeolite have many interesting applications in separation and bacteriostatic activity. materials and methods: template free zsm-5 zeolite was synthesized by hydrothermal method, physical hydrogels of nano chitosan in the colloidal domain were obtained in the absence of toxic organic solvent and then nano chitosan/zsm-5 hybrid composites with nano chitosan...

G protein-coupled receptors (GPCRs) have been proven to be the largest family of druggable targets in the human genome. Given the importance of GPCRs as drug targets and the de-orphanization of novel targets, GPCRs are likely to remain the frequent targets of many drug discovery programs. With recent advances in instrumentation and understanding of cellular mechanisms for the signals measured, ...

The carbohydrate-binding proteins galectin-1 and galectin-3 are found in the nucleus of cells. Using a cell-free assay, depletion and reconstitution experiments have documented that these two proteins are required factors in pre-mRNA splicing. Thiodigalactoside, which binds to both galectins, inhibited the splicing reaction, whereas cellobiose, which binds neither protein, failed to yield the s...

Abstract In continuation of the research, phytochemical investigation Capparis dongvanensis (Sy, B. H. Quang & D. V. Hai) (Capparaceae). this work, we described isolation and identification two novel polycyclic compounds Capparisone A ( 1 ) B 2 ). The structures these were determined based on NMR spectral data mass spectrometry. Furthermore, evaluated inhibitory activities isolated from C. ...

Scorpion venom toxicity is of major concern due to its influence on human activities and public health. We investigated the in-vitro process of cell death caused by two Iranian scorpions Odontobuthus doriae and Bothutus salceyi venom on human cell lines. The aim of this study was to provide further information about triggering cell death and suggestion of methods for the elimination of unwanted...

Introduction: CSCs have been identified in prostate cancer (PCa), one of the most diagnosed malignancies in men over the world, for which radiation resistance is a major problem in the treatment of advanced stages. Cancer stem cells (CSCs) have the ability to self-renew and differentiate to give rise to heterogeneous phenotype of the tumor cells. It is believed that CSCs are ...

BACKGROUNDS Previously, we demonstrated that neutralizing capacity but not the concentration of GM-CSF autoantibody was correlated with the disease severity in patients with autoimmune pulmonary alveolar proteinosis (PAP)¹⁻³. As abrogation of GM-CSF bioactivity in the lung is the likely cause for autoimmune PAP⁴⁻⁵, it is promising to measure the neutralizing capacity of GM-CSF autoantibodies fo...

The COVID-19 pandemic caused by SARS-CoV-2 has posed a global threat to human lives and economics. One of the best ways determine protection against infection is quantify neutralizing activity serum antibodies. Multiple assays have been developed validate neutralization; most them utilized lentiviral or vesicular stomatitis virus-based particles pseudotyped with spike (S) protein, making safe a...