To evaluate the occurrence, abundance, distribution, nature and clinical significance of multinucleated giant cell (MGC) in esophageal cancer. MGCs were examined with conventional pathology, immunohistochemistry immunofluorescence 107 cancer tissues. The findings correlated to pathological diagnosis behavior cancers. identified 31.7% (34/107) cases. positive for CD11c, CD11b, CD32, CD16, HLA-DR...

Background Rescue of exhausted T cell immunity through the inhibition PD-1/PD-L1 interaction is a pillar immunotherapeutic anti-PD-1 monoclonal antibodies (mAbs), as Nivolumab and Pembrolizumab. Despite IgG4 subclass, mAbs can bind different FcγRs trigger immunosuppressive activity in FcR-expressing myeloid cells. This effect evident when engage soluble PD-1 (sPD-1) forming stable sPD-1-antiPD-...

Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of multiple inflammatory markers in the brains of 28 non-immunized patients with Alzheimer's disease and 11 patients with Alzheimer's disease immunized against amyloid-β42 (AN1792): microglial ionized calcium-binding adaptor Iba-1, lysosome m...

UNLABELLED BACKGROUND A history of prolonged and excessive consumption of alcohol increases the risk for infections. The goal of this study was to investigate circulating white blood cells (WBC) differentiated by flow cytometry and neutrophil CD64 expression in excessive alcohol drinkers versus abstinent or moderate drinkers, and in those with or without infection, in medical patients admitt...