BACKGROUND Allergic asthma is strongly associated with the exposure to house dust mite (HDM) and is characterized by eosinophilic pulmonary inflammation and airway hyperresponsiveness (AHR). Recently, there is an increased interest in using dietary oligosaccharides, also known as prebiotics, as a novel strategy to prevent the development of, or reduce, symptoms of allergy. AIM We investigated...

Epilepsy is a common affliction that involves inflammatory processes. There are currently no definitive chemical diagnostic biomarkers in the blood, so diagnosis is based on a sometimes expensive synthesis of clinical observation, radiology, neuro-psychological testing, and interictal and ictal EEG studies. Soluble ICAM5 (sICAM5), also known as telencephalin, is an anti-inflammatory protein of ...

A series of pyrido[2,3-d]pyrimidine derivatives were designed and synthesized based on known CC chemokine receptor 4 (CCR4) antagonists. The activities of all the newly synthesized compounds were evaluated using a chemotaxis inhibition assay. Compound 6b was proven to be a potent CCR4 antagonist that can block cell chemotaxis induced by macrophage-derived chemokine (MDC), thymus and activation ...

Epigenetic changes have been implicated in silencing several B-cell genes in Hodgkin and Reed-Sternberg cells (HRS) of Hodgkin lymphoma (HL), and this mechanism has been proposed to promote HRS survival and escape from immunosurveillance. However, the molecular and functional consequences of histone deacetylase (HDAC) inhibition in HL have not been previously described. In this study, we report...

Macrophages affect the magnitude and duration of inflammatory response in a functionally heterogeneous manner. The phenotype of macrophages is maintained through a reversible homeostatic mechanism. A number of determinants that modulate macrophage plasticity have been identified, although the precise mechanisms are not fully understood. In this study, we report that stimulation of isolated huma...

Inducible co-stimulator (ICOS), a member of the CD28 coreceptor family, is costimulatory immune checkpoint receptor expressed on activated T-cells. Its ligand, ICOS ligand (ICOSL), antigen-presenting cells such as B cells. The ICOS-ICOSL axis plays an essential role in survival memory and effector T-cells responses, engagement by ICOSL induces proliferation, survival, cytokine production. Altho...

Our knowledge of atopic dermatitis/AD is largely derived from whole skin biopsies, which may cause scarring and infection. Tape strips are a minimally invasive technique to collect samples. A study directly differentiating the two approaches unavailable. We thus compared transcriptomic profile lesional AD as captured by tape biopsies taken 20 moderate-to-severe patients healthy controls. perfor...