BACKGROUND Occurrence of a stroke is a major concern in patients undergoing coronary artery bypass grafting (CABG). It remains uncertain whether significant asymptomatic carotid artery stenosis (CAS) is associated with stroke incidence in such patients. AIM To investigate the incidence of cerebrovascular events, myocardial infarction (MI), and death in patients with a significant asymptomatic...

We consider the automatic determination of application-specific memory subsystems via superoptimization, with the goals of reducing memory access time and of minimizing writes. The latter goal is of concern for memories with limited write endurance. Our subsystems outperform general-purpose memory subsystems in terms of performance, number of writes, or both.

Hypertrophic terminally differentiated cardiac myocytes show increased sarcomeric organization and altered gene expression. Previously, we established a role for the nonreceptor tyrosine kinase Src in signaling cardiac myocyte hypertrophy. Here we report evidence that p130Cas (Cas) and focal adhesion kinase (FAK) regulate this process. In neonatal cardiac myocytes, tyrosine phosphorylation of C...

Abstract Electrochemical biosensors continue to evolve at an astonishing pace, consolidating as competitive tools for determining a wide range of targets and relentlessly strengthening their attributes in terms sensitivity, selectivity, simplicity, response time, antifouling ability, making them suitable getting foothold real‐world applications. The design exploitation nanostructured or multifu...

L'objectif de ce travail etait de déterminer l'épidémiologie, la clinique et la thérapeutique des otites externes (OE). Il s'agissait d'une étude rétrospective d'une année menée du 1 janvier au 31 décembre 2006 dans le service ORL du CHU-Tokoin. Huit cent un cas d'otite externe (OE) soit 11,9% des consultations étaient recensés. Le sexe féminin représentait 476 cas (59,42%). Le sex ratio était ...

Background: While CRISPR-Cas systems have been identified in bacteria from a wide variety of ecological niches, there are no studies to describe CRISPR-Cas elements in Bacteroides species, the most prevalent anaerobic bacteria in the lower intestinal tract. Microbes of the genus Bacteroides make up ~25% of the total gut microbiome. Bacteroides fragilis comprises only 2% of the total Bacteroides...

dans la plupart des cas, la reponse des differents systemes juridiques aux questions juridiques est identique ou rapprochee. ceci se justifie, sans doute, par le fait que la raison humaine ala recherche de solutions pour les problemes juridique arrive aux memes resultants, meme si ceux s'expriment differemment, la derogation au principe pacta sunt servanda sous certaines conditions en est ...

Many concurrent data-structure implementations – both blocking and non-blocking – use the well-known compare-and-swap (CAS) operation, supported in hardware by most modern multiprocessor architectures, for inter-thread synchronization. A key weakness of the CAS operation is its performance in the presence of memory contention. When multiple threads concurrently attempt to apply CAS operations t...

Cas is a multidomain signaling protein that resides in focal adhesions. Cas possesses a large central substrate domain containing 15 repeats of the sequence YXXP, which are phosphorylated by Src. The phosphorylation sites are essential for the roles of Cas in cell migration and in regulation of the actin cytoskeleton. We showed previously that Src catalyzes the multisite phosphorylation of Cas ...