Recent studies have reported that cognitive inflexibility associated with impairments in a frontal-striatal circuit and parietal region is a core cognitive deficit of obsessive-compulsive disorder (OCD). However, few studies have examined progressive changes in these regions following clinical improvement in obsessive-compulsive symptoms. To determine if treatment changes the aberrant activatio...

The purpose of this study was to quantify the extent to which subjective ratings of craving for alcohol in the alcohol-abusing or dependent person (herein, alcoholic) correlate with measurable and specific characteristics of obsessions and compulsions. The Yale-Brown Obsessive Compulsive Scale modified to reflect obsessionality and compulsivity specifically related to heavy drinking (Y-BOCS-hd)...

Deep brain stimulation (DBS) is under investigation as a treatment for therapy-refractory obsessive-compulsive disorder (OCD). As crucial part of the anxiety circuit, bed nucleus stria terminalis (BNST) has been proposed target DBS in OCD. Here, we investigate clinical outcomes and safety BNST series 11 participants with severe Eleven consecutive diagnosed refractory OCD were treated completed ...

Objective: Obsessive compulsive disorder (OCD) is chronic psychiatric disorder with high rate of relapse during the course of illness. It is not well known which factors contribute for the chronicity of the illness, mainly because there are confounding factors as the medication effect. In this study we compared the difference of neurocognitive functions of the first-episode, medication-naive OC...

Objective: Obsessive compulsive disorder (OCD) is chronic psychiatric disorder with high rate of relapse during the course of illness. It is not well known which factors contribute for the chronicity of the illness, mainly because there are confounding factors as the medication effect. In this study we compared the difference of neurocognitive functions of the first-episode, medication-naive OC...

Objective: Obsessive compulsive disorder (OCD) is chronic psychiatric disorder with high rate of relapse during the course of illness. It is not well known which factors contribute for the chronicity of the illness, mainly because there are confounding factors as the medication effect. In this study we compared the difference of neurocognitive functions of the first-episode, medication-naive OC...

OBJECTIVE Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) region has shown promise as a neurosurgical intervention for adults with severe treatment-refractory obsessive-compulsive disorder (OCD). Pilot studies have revealed improvement in obsessive-compulsive symptoms and secondary outcomes following DBS. We sought to establish the long-term safety and effectiveness...

background: there is growing evidence for neuropsychology dysfunction in obsessive compulsive disorder (ocd) and posttraumatic stress disorder (ptsd). moreover, the phenomenological, etiological and neurological relationship between these two disorders lead to raising this question whether there is any difference in ptsd and ocd patient’s performance on verbal and nonverbal memory. methods: twe...

background due to the lack of enough researches on the impaired underlying mechanisms in the obsessive-compulsive disorder (ocd) and also existence of new psychological therapies such as metacognitive therapy and neurofeedback, the application of mentioned mechanisms in the new therapies can be introduced as a possible effective option with more long term effects to treat ocd. objectives the cu...