The chemokine CXCL12 and its G-protein-coupled receptor CXCR4 control the migration, invasiveness and metastasis of breast cancer cells. Binding of CXCL12 to CXCR4 triggers activation of heterotrimeric Gi proteins that regulate actin polymerization and migration. However, the pathways linking chemokine G-protein-coupled receptor/Gi signalling to actin polymerization and cancer cell migration ar...

The human estrogen receptor alpha (ERα) mediates the proliferative action of hormones in breast cancer cells by regulating the expression of target genes to control cellular functions. Current methodologies do not permit a real-time assessment of these processes in living cells. We overcome this limitation using electrical cell-substrate impedance sensing for measuring ERα-regulated signaling p...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

The stimulatory NKG2D receptor on lymphocytes promotes tumor immune surveillance by targeting ligands selectively induced on cancer cells. Progressing tumors counteract by employing tactics to disable lymphocyte NKG2D. This negative dynamic is escalated as some human cancer cells co-opt expression of NKG2D, thereby complementing the presence of its ligands for autonomous stimulation of oncogeni...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Epidermal growth factor receptor (EGFR) signaling is one of the crucial factors in breast cancer malignancy. Breast cancer cells often overexpress Arf6 and its effector, AMAP1/ASAP1/DDEF1; in these cells, EGFR signaling may activate the Arf6 pathway to induce invasion and metastasis. Active recycling of some integrins is crucial for invasion and metastasis. Here, we show that the Arf6-AMAP1 pat...

Primary breast lymphoma (PBL) is a clinicopathological entity characterized by the appearance of a unilateral breast mass of months of evolution, infrequently accompanied by signs of skin edema, retraction, erythema and nipple involvement. This rare situation is especially observed during pregnancy or postpartum, suggesting that tumor growth is influenced by hormonal stimulation, although its a...

Breast cancer is the most common cause of cancer death among women worldwide. In order to improve the treatment of this disease, a more complete understanding of its biological basis is necessary. Since the Hedgehog (Hh) pathway was recently found to be required for growth and propagation of a number of different cancers, we discuss here the possible involvement of this pathway in the normal bi...