The pre- and post-junctional alpha-adrenoceptor blocking agent, phentolamine, was given by intravenous infusion to eight healthy volunteers during rest, forearm exercise and post-exercise. Phentolamine produced a sustained increase in heart rate. The diastolic blood pressure decreased slightly whereas systolic and mean blood pressures remained unchanged. Phentolamine caused a marked increase in...

The aim of this study was to determine whether the decreased muscle and blood lactate during exercise with hyperoxia (60% inspired O2) vs. room air is due to decreased muscle glycogenolysis, leading to decreased pyruvate and lactate production and efflux. We measured pyruvate oxidation via PDH, muscle pyruvate and lactate accumulation, and lactate and pyruvate efflux to estimate total pyruvate ...

The levels of blood gases and energy metabolites strongly influence the outcome of animal experiments, for example in experimental stroke research. While mice have become prominent animal models for cerebral ischemia, little information is available on the effects of anesthetic drugs on blood parameters such as blood gases, glucose and lactate in this species. In this work, we collected arteria...

OBJECTIVE To compare cardiac troponin T release and lactate metabolism in coronary sinus and arterial blood during uncomplicated coronary grafting on the beating heart with conventional coronary grafting using cardiopulmonary bypass. DESIGN A prospective observational study with simultaneous sampling of coronary sinus and arterial blood: before and 1, 4, 10, and 20 minutes after reperfusion f...

One-lung ventilation is used during a variety of surgical procedures, even in patients with pre-existing coronary artery disease. The study purpose was to elucidate if myocardial metabolism crosses the anaerobic threshold under hypoxemia during one-lung ventilation. Therefore, we determined myocardial metabolism as a marker for anaerobic myocardial metabolism in patients with significant multi-...

Cardiac lymph in dogs was used to study the metabolism and state of the myocardium during extracorporeal circulation and various additional procedures. Changes in the flow characteristics, cdor and pH of lymph were noted, and corresponding samples of cardiac lymph and coronary sinus blood were analyzed for lactate concenlmtion. Ventricular fibrillation led to higher lactate levek when compared ...

1 A 24-year-old woman, who was normally fit and well, presented to the emergency department with abdominal pain, nausea and vomiting. She was noted to have scleral jaundice and admitted to taking a paracetamol overdose 24 hours previously. Blood tests were sent. On examination, she appeared drowsy when trying to get a full history. An arterial blood gas revealed pH of 7.38 (7.35–7.45), plasma g...

CONTEXT The partial pressure of venous to arterial carbon dioxide gradient (PCO2 gap) is considered as an alternative marker of tissue hypoperfusion and has been used to guide treatment for shock. AIMS The aim of this study was to investigate the prognostic value of venous-to-arterial carbon dioxide difference during early resuscitation of patients with septic shock and compared it with that ...

Introduction The early postoperative period after liver transplantation is characterized by a complex hemodynamic situation, due to the interaction of multiple factors, as the persistence of the hyperdynamic circulation or the increase of lactate blood levels because of the impaired hepatic clearance.The central venous-to-arterial carbon dioxide difference (PCVACO2 gap) has been proposed to bet...