Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.

The biomolecular approach to major depression disorder is explained by the different steps that involve cell membrane viscosity, Gsalpha protein and tubulin. For the first time it is hypothesised that a biomolecular pathway exists, moving from cell membrane viscosity through Gsalpha protein and Tubulin, which can condition the conscious state and is measurable by electroencephalogram study of t...

An overview of optical biomolecular imaging is provided. Following a brief history of the development of probes and technologies in this area, general approaches which use biomolecular imaging in current commercial systems are discussed. A brief summary of research challenges in this area - in terms of both the chemistry and technique development - is introduced. Finally, areas rich for possibl...

Catherine A. Fox and Kristopher H. McConnell From the Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI, 53706 Running Title: Silencing the Yeast HMR Domain Address correspondence to: Catherine A. Fox, Associate Professor, Department of Biomolecular Chemistry, 587 MSC, 1300 University Ave., University of Wisconsin Medical School, Madison, WI 53706-1532, T...