doi:10.1002/2211-5463.12410 Mitochondrial uncoupling protein-2 (UCP2) mediates free fatty acid (FA)dependent H translocation across the inner mitochondrial membrane (IMM), which leads to acceleration of respiration and suppression of mitochondrial superoxide formation. Redox-activated mitochondrial phospholipase A2 (mt-iPLA2c) cleaves FAs from the IMM and has been shown to acts in synergy with ...

The role of calcium-independent phospholipase A(2) (iPLA(2))-produced arachidonic acid (AA) in acetylcholine (ACh)-mediated, endothelium-dependent vascular relaxation was investigated. ACh-induced relaxation of phenylephrine-constricted isolated rat mesenteric resistance arteries was attenuated following pretreatment with (E)-6-(bromomethylene)tetrahydro-3-(1-naphthalenyl)-2H-pyran-2-one (BEL; ...

The electronic structure and reactivity of neutral tricoordinated Be(0) compounds BeL(3), L = CO (1), NHC (2) and PMe(3) (3) are explored by quantum mechanical calculations. These BeL(3) complexes are found to be planar or nearly planar like electron deficient BH3 but isoelectronic with NH3 and possess three L→Be donor-acceptor bonds. The Be atom can be considered as sp(2)-hybridized with a lon...

BACKGROUND During early treatment of haemorrhagic shock maintenance of cerebral and end-organ oxygen supply by fluid resuscitation is mandatory. Gelatin-polysuccinat (GP) recently regained attention despite a still unclear risk profile and widely unknown effects on cerebral and peripheral microcirculation. This study investigates the effects of GP versus balanced electrolyte solution (BEL) with...

Giri?: Dünyada ve ülkemizde önemli bir sa?l?k sorunu olan obezitenin olu?umuna pek çok faktör katk?da bulunmaktad?r. Sunulan çal??ma beslenme bilgi düzeyinin üniversite ö?rencilerindeki obezite üzerindeki etkisini ara?t?rmak amac?yla yap?lm??t?r. Yöntem: Çal??ma 252 ö?rencisi ile yürütülmü?tür. Antropometrik ölçümler (vücut a??rl???, boy uzunlu?u, bel, kalça çevresi) yap?lm?? beden kütle indeks...

BACKGROUND MicroRNAs (miRNAs) function as essential posttranscriptional modulators of gene expression, and are involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs are deregulated in hepatocellular carcinoma (HCC). This study aimed to investigate the role of miR-27a in the development of HCC. METHODS The expression of MiR-27a was measured by quantit...

Calcium-independent phospholipase A(2) (iPLA(2)) is the predominant phospholipase A(2) present in myocardium, and its pathophysiological role in acute myocardial infarction has been suggested by the rapid increase in membrane-associated iPLA(2) activity during myocardial ischaemia and reperfusion (I/R). We therefore examined iPLA(2) in mitochondrial fractions prepared from Langendorff-perfused ...

We have previously shown that the regulation by interleukin-1b (IL-1b) of inducible nitric oxide synthase (iNOS) involves phospholipase A2 (PLA2) metabolites in neonatal ventricular myocytes. Based on studies in which ONO-RS-082 is used to inhibit secretory PLA2 and methyl arachidonyl fluorophosphonate is used to inhibit cytosolic PLA2, our data suggest that a secretory PLA2 metabolite was invo...

Phospholipase A(2) (PLA(2)), a regulatory enzyme found in most mammalian cells, catalyzes the breakdown of membrane phospholipids to arachidonic acid. There are two major cytosolic types of the enzyme, calcium-dependent (cPLA(2)) and calcium-independent (iPLA(2)) PLA(2). The present study investigated whether or not iPLA(2) plays a role in the endothelium-dependent contractions of the aorta of ...

Urotensin II and the associated urotensin II receptor (UTR) are important in the carcinogenesis of hepatocellular carcinoma (HCC). However, the clinical significance of UTR remains to be elucidated. The aim of the present study was to investigate if UTR exhibits the potential to act as a biomarker to predict the prognosis of HCC patients. The effects of UTR on motility and invasion of HCC cells...