Muthusamy, Saraladevi (2016). Functional Profiling of Metabolic Regulation in Marine Bacteria, Linnaeus University Dissertation No 245/2016, ISBN: 978-91-88357-07-6. Written in English. Oceans are powered by active, metabolically diverse microorganisms, which are important in regulating biogeochemical cycles on Earth. Most of the ocean surface is often limited by nutrients, influencing bacteria...

UNLABELLED The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions. In Enterococcus faecalis, production of (p)ppGpp is controlled by the bifunctional protein RSH (for "Rel SpoT homologue"; also known as RelA) and by the monofunctional synthetase RelQ. Previ...

Background: Storage of platelet concentrates (PCs) at room temperature (20-24°C) limits its storage time to 5 days due to the destructive effects of platelet storage lesion (PSL) and bacterial contamination. Although prolonged storage of platelets (PLTs) at 4°C reduces the likelihood of bacterial contamination and PSL levels, it is accompanied by an increase in the clearance rate and changes in...

OBJECTIVE The capacity for local infection to prolong survival in patients with cancer is a widely accepted but unsubstantiated principle. The neurosurgical literature contains anecdotal reports of patients with malignant gliomas who experienced prolonged remission of their tumors after a bacterial infection. This association has not been explored in a larger series of patients with malignant g...

Regarding the influence of ultraviolet irradiation on the growth of bacteria, numerous studies have been accomplished and it has been known that there exists a relation of exponential function between the bactericidal effect and the amount of ultraviolet ray irradiated. The methods employed in those studies,1),2),3),4) a,b, however, are mostly so called plate method in which the irradiation is ...

Purpose: To develop an experimental model of intestinal ischemia and obstruction followed by surgical resection of the damaged segment and reestablishment of intestinal transit, looking at bacterial translocation and survival. Methods: After anesthesia, Wistar rats was subject to laparotomy, intestinal ischemia and obstruction through an ileal ligature 1.5cm of ileum cecal valve; and the mese...

A localized and effective innate immune response to pathogenic bacterial invasion is central to host survival. Identification of the critical local innate mediators of lung defense against such pathogens is essential for a complete understanding of the mechanism(s) underlying effective host defense. In an acute model of Streptococcus pneumoniae lung infection, deficiency in matrix metalloprotei...

Two parameters are commonly used for the evaluation of antibiotic efficacy in animal models: bacterial counts in tissue fluids and survival rate. The second parameter is easy to assess and seems more relevant from the clinical perspective; a curative dose is used as a reliable end-point for showing subtle differences in antibiotic behaviour. Reduction in bacterial counts provides information on...

The human complement system plays an important role in the defense against invading pathogens, inflammation and homeostasis. Invading microbes, such as bacteria, directly activate the complement system resulting in the formation of chemoattractants and in effective labeling of the bacteria for phagocytosis. In addition, formation of the membrane attack complex is responsible for direct killing ...

Microbial identification using effluents backflushed from exhausted urban and rural tank resins and cleaned resins containing the sulfonated copolymer of styrene and divinylbenzene (SDB) were completed, along with microbial assessment of the concentrated stock salt brine. Forty-four different bacterial and fungal genera were identified. Extensive biochemical and animal virulence tests completed...