Background: Predicting intrinsically disordered proteins is important in structural biology because they are thought to carry out various cellular functions even though they have no stable three-dimensional structure. We know the structures of far more ordered proteins than disordered proteins. The structural distribution of proteins in nature can therefore be inferred to differ from that of pr...

for the Environment has created the Environmental Fellows program to enable recent doctorate recipients to use and expand Harvard's extraordinary resources to tackle complex environmental problems. The Environmental Fellows will work for two years with Harvard faculty members in any school or department to create new knowledge while also strengthening connections across the university's academi...

tions in the phenotype, repertoire and activation status of lymphocytes as well as in the cytokine profile produced by these cells. As a lifelong condition, chronic parasitic diseases such as human schistosomiasis overlaps with the aging process and no systematic study has yet addressed the changes in immune response during infection with Schistosoma mansoni in older individuals. Aim : Herein w...

OnFebruary 27, 2011, Hollywood’s royalty will gather in Kodak Theater to honor the best films of 2010. To add a scientific twist on this year’s Academy Awards, Cell Culture dives beneath the skin of the top films’ protagonists, identifying a brain structure that impacts our ‘‘friend count,’’ genes that make a king stammer, a cellular fragmentation process that saves a solo hiker, and stem cells...

announce their intent to support a special awards competition opening in fiscal year 2002. For this awards competition, the EPA and the NSF are jointly soliciting grant applications that focus on the Decision-Making and Valuation for Environmental Policy (DMVEP) research area. The online announcement of the DMVEP awards competition and application forms are available at http://es.epa. gov/ncer/...

Background: Although sentinel lymph node (SLN) biopsy is a standard of care for the evaluation of the axillary lymph nodes during breast cancer surgery, a substantial degree of variation exists among individual surgeons as to what represents an adequate assessment. The aim of the current study was to assess when metastatic disease was first identified within consecutively harvested SLN candidat...

1 Epilepsy Center, University Hospital Freiburg, Freiburg, Germany, 2 Heidelberg Academy of Science and Humanities, Heidelberg, Germany, 3 Freiburg Brain Imaging, University Hospital Freiburg, Freiburg, Germany, 4 Bernstein Center for Computational Neuroscience Freiburg, Freiburg, Germany, 5 Neurobiology and Animal Physiology, Institute for Biology I, University of Freiburg, Freiburg, Germany, ...

The levels of mRNA for transforming growth factors (TGF alpha and beta) and the epidermal growth factor receptor (EGFR) were determined in 69 human breast carcinomas and 20 biopsies of nonneoplastic breast tissue by dot blot hybridisation analysis. TGF alpha mRNA was detected in 42% of cancers and 44% of non-neoplastic breast tissue at low levels. TGF beta mRNA was found in all breast cancers a...