The Catharanthus roseus plant is the source of many valuable terpenoid indole alkaloids (TIAs), including the anticancer compounds vinblastine and vincristine. Transcription factors (TFs) are promising metabolic engineering targets due to their ability to regulate multiple biosynthetic pathway genes. To increase TIA biosynthesis, we elicited the TIA transcriptional activators (ORCAs and other u...

BACKGROUND Infectious diseases due to multidrug-resistant bacteria are one of the causes of treatment failures contributing to an increase in mortality and/or morbidity. In this study, we evaluated the antibacterial potential of different parts of six medicinal plants namely Alstonia boonei, Ageratum conyzoides, Croton macrostachys, Cassia obtusifolia, Catharanthus roseus and Paullinia pinnata ...

In addition to canthaxanthin, seven pigment fractions were isolated from Micrococcus roseus. They were purified by solvent partitioning and by column and thin-layer chromatography. Visible absorption spectra, chromatographic behavior, and partition coefficients of the pigments and derivatives prepared from the pigments were used in characterizing them. Both alpha- and beta-carotene derivatives ...

Catharanthus roseus, Cell Suspension C ultures, T ryp tophan A nalogues, R esistant Cell Lines, Tryptophan Decarboxylase, Indole A lkaloids Cell lines o f Catharanthus roseus were selected for resistance to 4 -m ethyltryptophan (4-M T) in order to get strains with increased activities o f tryp tophan decarboxylase (TD C ). This enzym e may exert a decisive regulatory control in indole alkalo id...