PEARLS Limbic encephalitis is an inflammatory condition of the brain, often characterized by the subacute onset of short-term memory loss, disorientation, seizures, behavioral disturbance, and psychiatric symptoms. Besides paraneoplastic syndromes with onconeural antibodies targeted against intracellular neuronal antigens, limbic encephalitis may also arise from nonparaneoplastic mechanisms wit...

Acute ototoxicity is a rare but important complication of antithyroid drugs. Although previous cases have been reported in the medical literature, these cases occurred in younger patients with serological evidence of lupus-like syndrome with positive antidouble-stranded deoxyribonucleic acid and antineutrophil cytoplasmic antibodies. We describe the case of a 68-year-old Caucasian male who deve...

Some alkyl and aryl derivatives of 9H-purine-6-thiol were synthesized and evaluated in vitro and in vivo for potential antithyroid effects. Spectrophotometric studies demonstrated 1:1 charge transfer complexation between iodine and these compounds with quite high values of the formation constants. The blood assays of rats treated with these compounds revealed significant antithyroid activity fo...

The first studies on thiourea in this department were undertaken for reasons quite apart from the purposes for which it is now used. It had been reported that this compound distributed itself uniformly throughout the fluids of the body, that it was excreted like urea and could be recovered in the urine, completely, unchanged.31 These characteristics, if they could be verified, would make thiour...

Thyrotoxicosis occurs in about 0.2% of pregnancies and is caused most frequently by Graves disease (Burrow, ’85; Kriplani et al., ’94). Graves disease is an autoimmune disorder characterized by the production of antibodies, immunoglobulins of the IgG class, directed against thyroid stimulating hormone (TSH) receptors (Shoenfeld and Schwartz, ’84). This results in the excess production of thyroi...

Autoimmune diseases may be related with the development of a secondary autoimmune disorder. We, herein, report a case (31 years old female) of idiopathic thrombocytopenic purpura responding to antithyroid treatment in a patient with Graves Opthalmopathy (GO). The relation between Idiopathic Thrombocytopenic Purpura (ITP) and Graves Disease (GD) is not well known. In the current case, recovery f...

Chronic idiopathic urticaria (CIU) is well known to be associated with antithyroid peroxidase antibodies and autoimmune thyroiditis. Coexisting Graves disease has only rarely been observed. We describe 2 patients with CIU who developed autoimmune hyperthyroidism with antithyrotropin receptor antibodies. Antithyroid peroxidase antibodies were also present in 1 of the patients, but both responded...

In three patients with thyrotoxicosis and with symptomatic hypercalcaemia antithyroid therapy restored the plasma calcium concentration to normal, though initially in one case intravenous and oral neutral phosphate solution were required to curtail intractable vomiting.Nine cases have been recorded in which the plasma calcium concentration returned to normal after antithyroid treatment was star...

Background: Polycystic Ovarian Syndrome (PCOS) is common but a treatable cause of infertility in reproductive women. Thyroid hormone abnormality commonly seen Antithyroid antibodies have been detected women with PCOS. The aim the present study to evaluate antithyroid women.
 Materials and methods: A hospital based cross-sectional comparative was conducted outpatient Department Obstetrics G...